Lifetime exposure of ambient PM2.5 elevates intraocular pressure in young mice.
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In this article, young mice were exposed to concentrated ambient PM2.5 (CAP) for 9 months, which is throughout most of the life span of a mouse under heavy pollution.About:
This article is published in Ecotoxicology and Environmental Safety.The article was published on 2021-11-12 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Intraocular pressure.read more
Citations
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Ambient particulate matter exposure causes visual dysfunction and retinal neuronal degeneration.
TL;DR: In this article , the adverse effects of PM2.5 exposure on visual function and retinal neurons were investigated using a versatile aerosol concentration enrichment system, where mice were exposed to either control air or PM 2.5 polluted air.
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Acute exposure to air pollutants increase the risk of acute glaucoma
TL;DR: Wang et al. as mentioned in this paper investigated the effect of air pollutants on the incidence of acute glaucoma (acute angle closure glaucomba and glauchatocyclitic crisis) among adults.
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Overview of PM2.5 and health outcomes: Focusing on components, sources, and pollutant mixture co-exposure.
TL;DR: In this article , a comprehensive understanding of the effect of PM2.5 on human health is discussed, which can be used to draft effective policies to provide a foundation for precise PM 2.5 emission control.
References
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The health effects of ambient PM2.5 and potential mechanisms
TL;DR: A brief overview of new insights into the molecular mechanisms linking ambient PM2.5 exposure and health effects are provided, which were explored with new technologies in recent years.
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The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium.
TL;DR: The "funneling" hypothesis that has emerged as a leading synergistic model is closely examined, and the basis of funneling, mechanical and biological requirements for funneling and evidence in support of this hypothesis are reviewed.
Journal Article
Oxygen and blood flow: players in the pathogenesis of glaucoma
TL;DR: The association between IOP increase and these factors is relatively weak but nevertheless significant, and factors associated with disturbed autoregulation, in particular a systemic primary vascular dysregulation (PVD), increase the risk for GON.
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Aqueous humor dynamics in mice.
TL;DR: The mouse eye has similar aqueous production and aQueous humor turnover rate as the human eye and the presence of both conventional and uveoscleral outflow suggests that the mouse is a useful model system for further investigations of the biology of aqueously dynamics.
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Glaucoma in Adults-Screening, Diagnosis, and Management: A Review.
TL;DR: Open-angle and narrow-angle forms of glaucoma are reviewed in this article, including a description of the pathophysiology, risk factors, screening, disease monitoring, and treatment options.