Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US.
Elena Losina,Alexander M. Weinstein,William M. Reichmann,Sara A. Burbine,Daniel H. Solomon,Meghan E. Daigle,Benjamin N. Rome,Stephanie Chen,David J. Hunter,Lisa G. Suter,Joanne M. Jordan,Jeffrey N. Katz +11 more
Reads0
Chats0
TLDR
To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self‐reports in the US population, data are collected on men, women, and children aged between 18 and 74.Abstract:
Objective
To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population.
Methods
We estimated the incidence of diagnosed symptomatic knee OA in the US by combining data on age-, sex-, and obesity-specific prevalence from the 2007–2008 National Health Interview Survey, with disease duration estimates derived from the Osteoarthritis Policy (OAPol) Model, a validated computer simulation model of knee OA. We used the OAPol Model to estimate the mean and median ages at diagnosis and lifetime risk.
Results
The estimated incidence of diagnosed symptomatic knee OA was highest among adults ages 55–64 years, ranging from 0.37% per year for nonobese men to 1.02% per year for obese women. The estimated median age at knee OA diagnosis was 55 years. The estimated lifetime risk was 13.83%, ranging from 9.60% for nonobese men to 23.87% in obese women. Approximately 9.29% of the US population is diagnosed with symptomatic knee OA by age 60 years.
Conclusion
The diagnosis of symptomatic knee OA occurs relatively early in life, suggesting that prevention programs should be offered relatively early in the life course. Further research is needed to understand the future burden of health care utilization resulting from earlier diagnosis of knee OA.read more
Citations
More filters
Journal ArticleDOI
Ageing and the pathogenesis of osteoarthritis
TL;DR: Improved understanding of ageing-related mechanisms that promote OA could lead to the discovery of new targets for therapies that aim to slow or stop the progression of this chronic and disabling condition.
Journal ArticleDOI
The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study
L E Bayliss,David Culliford,A Paul Monk,Sion Glyn-Jones,Daniel Prieto-Alhambra,Daniel Prieto-Alhambra,Daniel Prieto-Alhambra,Andrew Judge,Andrew Judge,Cyrus Cooper,Cyrus Cooper,Andrew Carr,Nigel K Arden,Nigel K Arden,David J Beard,Andrew Price +15 more
TL;DR: The evidence challenges the increasing trend for more total hip replacements and total knee replacements to be done in the younger patient group, and these data should be offered to patients as part of the shared decision making process.
Journal ArticleDOI
Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review.
TL;DR: In this paper, a review of hip and knee OA is presented, focusing on the most common reason for activity limitation in adults. But, the authors do not discuss the treatment of OA in the context of total joint replacement.
Journal ArticleDOI
Number of Persons With Symptomatic Knee Osteoarthritis in the US: Impact of Race and Ethnicity, Age, Sex, and Obesity.
Bhushan R. Deshpande,Jeffrey N. Katz,Daniel H. Solomon,Edward H. Yelin,David J. Hunter,Stephen P. Messier,Lisa G. Suter,Elena Losina +7 more
TL;DR: The prevalence of symptomatic knee osteoarthritis has been increasing over the past several decades in the US, concurrent with an aging population and the growing obesity epidemic and the impact of these factors on the number of persons with symptomatic knees OA in the early decades of the 21st century is quantified.
Journal ArticleDOI
Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory.
TL;DR: A mechanism-based rationale for the use of HA in some disease conditions with special reference to OA is provided, and the MW of HA appears to play a critical role in the formulation of the products used in the treatment of diseases.
References
More filters
Journal ArticleDOI
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.
Reva C. Lawrence,David T. Felson,Charles G. Helmick,Lesley M. Arnold,Hyon K. Choi,Richard A. Deyo,Sherine E. Gabriel,Rosemarie Hirsch,Marc C. Hochberg,Gene G. Hunder,Joanne M. Jordan,Jeffrey N. Katz,Hilal Maradit Kremers,Frederick Wolfe +13 more
TL;DR: This report provides the best available prevalence estimates for the US for osteoarthritis, polymyalgia rheumatica, gout, fibromyalgia, and carpal tunnel syndrome as well as the symptoms of neck and back pain.
National Arthritis Data Work-group. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
Reva C. Lawrence,David T. Felson,Charles G. Helmick,LM Arnold,Hyon K. Choi,Richard A. Deyo,LM Helmick Cg Arnold,Sherine E. Gabriel,Rosemarie Hirsch,Marc C. Hochberg,Gene G. Hunder,Joanne M. Jordan,Jeffrey N. Katz,Hilal Maradit Kremers,Frederick Wolfe,FC Arnett +15 more
TL;DR: In this paper, the best available estimates of the US prevalence of and number of individuals affected by osteoarthritis, polymyalgia rheumatica and giant cell arteritis, gout, fibromyalgia, and carpal tunnel syndrome, as well as the symptoms of neck and back pain are provided.
Journal ArticleDOI
Obesity in children and young people: a crisis in public health.
TL;DR: The present report has been written to focus attention on the issue and to urge policy-makers to consider taking action before it is too late.
Journal ArticleDOI
The Obesity Epidemic in the United States—Gender, Age, Socioeconomic, Racial/Ethnic, and Geographic Characteristics: A Systematic Review and Meta-Regression Analysis
Youfa Wang,May A. Beydoun +1 more
TL;DR: Obesity has increased at an alarming rate in the United States over the past three decades and the associations of obesity with gender, age, ethnicity, and socioeconomic status are complex and dynamic.
Journal ArticleDOI
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
Marc C. Hochberg,Roy D. Altman,Karine Toupin April,Maria Benkhalti,Gordon H. Guyatt,Jessie McGowan,Tanveer Towheed,Vivian Welch,George A. Wells,Peter Tugwell +9 more
TL;DR: To update the American College of Rheumatology (ACR) 2000 recommendations for hip and knee osteoarthritis (OA) and develop new recommendations for hand OA.
Related Papers (5)
OARSI guidelines for the non-surgical management of knee osteoarthritis
Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee
Roy D. Altman,E. Asch,Daniel Bloch,Giles G. Bole,David G. Borenstein,Kenneth D. Brandt,Wallace C. Christy,Cooke Td,Robert A. Greenwald,Marc C. Hochberg,David S. Howell,David L. Kaplan,William J. Koopman,Selden Longley,Henry J. Mankin,Dennis J. McShane,Thomas A. Medsger,Robert F. Meenan,William M. Mikkelsen,Roland W. Moskowitz,William A. Murphy,B. Rothschild,Mark R. Segal,Leon Sokoloff,Frederick Wolfe +24 more