Ligating properties of model bioheterocyclics. Ill. Synthesis and characterization of the palladium(II) and platinum(II) Complexes with 3,6-disubstituted-2,7-dihydro-1,4,5-thiadinzepine derivatives
TL;DR: Palladium(II) and platinum (II) halides with 3,6-disubstituted 2,7-dihydro-1,4,5-thiadiazepine derivatives (L) form complexes of general formula as discussed by the authors.
About: This article is published in Inorganica Chimica Acta.The article was published on 1979-01-01. It has received 6 citations till now. The article focuses on the topics: Palladium & Double bond.
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TL;DR: The structures of dicyclohexyl-(18-crown-6) uranyl perchlorate, [(C20H36O6)UO2] (ClO4)2 (complex I) and of DICYCLOHENYL-(18crown 6)-URYXPERCHICATE (complex II) have been determined from three-dimensional X-ray diffraction data as discussed by the authors.
54 citations
TL;DR: Palladium and platinum are the longest known and most studied of the six platinum metals as discussed by the authors, a reflection of their abundance and consequent availability, and platinum occurs naturally as the element, generally with small amounts of other platinum metals.
32 citations
TL;DR: In this article, the seven-membered ring of 3,6-di(p-chlorophenyl)-2,7-dihydro-1,4,5-thiadiazepine, C16H12Cl2N2S, which crystallizes in the triclinic space group, P-1 with a coefficient of 8.4012, was solved by direct methods and refined by full-matrix least squares based on F2 with weight w.
Abstract: In 3,6-di(p-chlorophenyl)-2,7-dihydro-1,4,5-thiadiazepine, C16H12Cl2N2S, which crystallizes in the triclinic space group, P-1, with a = 8.4012(13) A, b = 9.2087(15) A, c = 10.4974(17) A, α = 69.835(3)°, β = 77.091(4)°, γ = 81.820(4)°, V = 741.2(2) A3 and Z = 2, the seven-membered ring adopts a distorted boat conformation. The structure was solved by direct methods and refined by full-matrix least squares based on F2 with weight w = 1/[σ2(
$$ {\text{F}}_{\text{o}}^{2} $$
) + (0.0018P)2 + 1.5600P] where P = (
$$ {\text{F}}_{\text{o}}^{2} $$
+
$$ 2 {\text{F}}_{\text{c}}^{2} $$
)/3. The new dnorm Hirshfeld surface and the breakdown of fingerprint plots were used for visualizing and exploring of title compound for quantifying intermolecular interactions in crystal lattice. Crystal structure and Hirshfeld surface analysis of 3,6-di(p-chlorophenyl)-2,7-dihydro-1,4,5-thiadiazepine have been reported.
11 citations
TL;DR: The thermal stability of a series of palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands was investigated using a combination of experimental measurements and DFT calculations as discussed by the authors.
6 citations
TL;DR: Palladium(II) halides form five-coordinate PdC2,(TDAN) complexes with 1,4,7thiadiazonines (TDAN), whereas platinum(II), chloride yields five coordinate [PtC2 · n H2O complexes in the solid state and four coordinate square planar [ptCl · n HO complexes in DMF solution.
Abstract: Palladium(II) halides form five-coordinate PdC2,(TDAN) complexes with 1,4,7-thiadiazonines (TDAN), whereas platinum(II) chloride yields five coordinate [PtC2,(TDAN)] · n H2O complexes in the solid state and four-coordinate square planar [PtCl(TDAN)]CI · n H2O complexes in DMF solution. Platinum(IV) chloride reacts with TDAN to form six-coordinate [PtCl3(TDAN)]CI · n H2O octahedral complexes. 1.4.7-Thiadiazonine behaves as a tridentate ligand and coordinatesvia all three heteroatoms (S. N and N) forming three mutually adjacent five membered chelate rings with the metal ion.
6 citations
References
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TL;DR: The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice and reversibly inhibit cell division in Gram-negative rods1–4.
Abstract: CERTAIN platinum compounds completely but reversibly iiihibit cell division in Gram-negative rods1–4. These compounds have been tested for antitumour activity and we report some of the preliminary results. The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice.
3,574 citations
389 citations
Journal Article•
TL;DR: In this paper, the platinum compounds, cisplatinum (IV) diamminotetrachloride and cis-platinum diamminodichloride, have been reported to be active in inhibiting and regressing small solid Sarcoma 180 tumors and Leukemia L1210 tumors in mice.
Abstract: Summary The platinum compounds, cis-platinum (IV) diamminotetrachloride, and cis-platinum (II) diamminodichloride, have been reported to be active in inhibiting and regressing small solid Sarcoma 180 tumors and Leukemia L1210 tumors in mice. They were also active in successfully regressing large (Day 8) solid Sarcoma 180 tumors in 63 to 100% of the animals, with no apparent irreversible damage to the host, in a number of dose schedules.
372 citations
TL;DR: In this article, the structure of monothio-β-diketones of general formula RC(SH)=CHCOR was established by mass and n.m.r. spectroscopy.
Abstract: Monothio-β-diketones of general formula RC(SH)=CHCOR? (R = Me, R* = Me, Ph, OEt; R = Ph, R' = Ph, OEt; R = α-thienyl, R' = CF3; and 12 = R' = CMe,) have been prepared in order to study their metal complexes. Five of these thio derivatives are new and were prepared by treatment of a dilute solution of the corresponding β-diketone in alcohol with hydrogen sulphide at low temperature. Mass spectrometric examination has established the structures of MeC(SH)=CHCOPh and RC(SH)=CHCOCF, (R = α-thienyl). The red compounds PhC(SH)=CHCOPh (VI) and MeC(SH)=CHCOPh (V) can be oxidized to yellow products. The structure of the yellow compound (XV) obtained from (VI) was established by mass and n.m.r. spectroscopy as the disulphide PhCOCH=C(Ph)SSC(Ph)=CHCOPh. The molecular ion of (XV) undergoes novel rearrangement reactions involving, inter alia, elimination of H2S to produce a thiophene ion. The nickel chelates Ni(RCS=CHCOR')2 are brown, diamagnetic, and soluble in organic solvents. Unstable paramagnetic bis-pyridine adducts, derived from two of the nickel chelates, were isolated. The infrared spectra of the monothio-β-diketones and their nickel chelates are reported. The spectra of the monothio-β-diketones show no SH band at c. 2570 cm-1 ; this indicates strong chelation of the thiol hydrogen between the sulphur and oxygen atoms. The monothio-β-diketones display four characteristic bands which are assigned as follows : 1670-1590 cm-1, v(C--O) ; 1638-1530 cm-1, v(C=C) ; 1267-1190 cm-1, v(C=S) ; 837-805 cm-1, provisionally assigned as v(C=S) + δ(C-H). The nickel chelates exhibit five characteristic bands: 1590-1535 cm-1, V(C=C); 1542-1477 cm-1, v(C-0); 1261-1220 cm-1, v(C--S); 817-800 cm-1, provisionally assigned to v(C-S)+ δ(C-H); 499-451 cm-1, v(Ni-O). No band corresponding to v(Ni-S) was detected above 250 cm-1. However, the metal-sulphur stretching frequency was observed as a peak of medium intensity within the range 360-308 cm-1 in the spectra of bis(o-methylthiobenzenethiolo)-nickel(II) and the diethyl dithiophosphate complexes of nicke1(II), palladium(II), chromium(III), and cobalt(III).
134 citations