Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
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Cites background from "Ligation of CD40 on dendritic cells..."
...Mature DCs resist the suppressive effects of IL-10, but synthesize high levels of IL-12...
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3,591 citations
Cites background from "Ligation of CD40 on dendritic cells..."
...The effect of these two cytokines is particularly noteworthy in the case of DCs, because IL-4 and IL-13 are often used for the generation of DCs in vitro from monocytes or haematopoietic precursors, thereby explaining the ability of DCs obtained in these culture systems to produce more IL-12 than ex vivo -purified DC...
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3,082 citations
2,676 citations
Cites background from "Ligation of CD40 on dendritic cells..."
...Ligation of CD40 on the surface of APCs such as dendritic cells, macrophages and B cells greatly increases their antigen-presentation and co-stimulatory capacit...
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2,466 citations
References
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4,872 citations
"Ligation of CD40 on dendritic cells..." refers background in this paper
...Dendritic cells (DCs) are professional APCs specialized in antigen capture, migration to secondary lymphoid organs and T cell pr iming (4-7)....
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3,193 citations
"Ligation of CD40 on dendritic cells..." refers background in this paper
...In a series of original experiments Murphy, O'Garra, and colleagues demonstrated that bacteria such as Listeria monocytogenes can stimulate macrophages to produce IL-12 and that this cytokine can act on bystander T cells that recognize antigen on different APCs (1)....
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...Our results suggest that immunization with a T helper epitope might facilitate priming of CTLs by targeting CD40L+ Thl cells on APCs....
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...I t is well established that IL-12 is responsible for the development of T h l responses (1-3)....
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...In a series o f original experiments Murphy, O'Garra, and colleagues demonstrated that bacteria such as Listeria monocytogenes can stimulate macrophages to produce IL-12 and that this cytokine can act on bystander T cells that recognize antigen on different APCs (1)....
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...Dendritic cells (DCs) are professional APCs specialized in antigen capture, migration to secondary lymphoid organs and T cell priming (4-7)....
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2,674 citations
1,700 citations
"Ligation of CD40 on dendritic cells..." refers background in this paper
...I t is well established that IL-12 is responsible for the development of T h l responses (1-3)....
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