Journal ArticleDOI
Linkage and selection: two locus symmetric viability model.
Samuel Karlin,Marcus W. Feldman +1 more
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TLDR
Many models analyzed in order to establish more rigorously how natural selection may have produced tightly linked clusters of loci and the evolution of supergenes can be realized as particular cases of what has become known as the symmetric viability model involving two loci with two alleles at each locus.About:
This article is published in Theoretical Population Biology.The article was published on 1970-05-01. It has received 181 citations till now. The article focuses on the topics: Complete linkage & Recombination Fraction.read more
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Evolution of sex
TL;DR: The Economy of Nature and the Evolution of Sex*.
Journal ArticleDOI
Linkage disequilibrium -understanding the evolutionary past and mapping the medical future
TL;DR: The linkage disequilibrium process, the nonrandom association of alleles at different loci, and the population genetic processes that affect it are reviewed.
Book ChapterDOI
The Evolutionary Significance of Genetic Diversity: Ecological, Demographic and Life History Correlates
TL;DR: The evolutionary significance of genetic diversity of proteins in nature remains controversial despite the numerous protein studies conducted electrophoretically during the last two decades.
Journal ArticleDOI
Epistasis and its contribution to genetic variance components.
TL;DR: A new parameterization of physiological epistasis is presented that allows the measurement of epistasis separate from its effects on the interaction (epistatic) genetic variance component, and allows general consideration of the role of Epistasis in evolution by defining its contribution to the additive genetic variance.
Journal ArticleDOI
Antagonistic pleiotropy, dominance and genetic variation
TL;DR: Though these models are not very robust, they do illustrate in principle one means of explaining recent experimental findings concerning the quantitative genetics of components of fitness in populations free of inbreeding.
References
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Journal ArticleDOI
The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.
TL;DR: The results of these investigations were sufficient to show that even for relatively simple cases (two loci, simple symmetrical selective values) linkage might have profound effects on the course of natural selection and, pari passu, natural selection may have major effect on the distribution of coupling and repulsion linkage in a population.
Journal ArticleDOI
The evolutionary dynamics of complex polymorphisms.
TL;DR: It is sufficient to note the vast effort made by Dobzhansky and his co-workers in their elucidation of the inversion polymorphism of the third chromosome of Drosophila pseudoobscura.