Journal ArticleDOI
Lipedema: a frequently misdiagnosed and misunderstood fatty deposition syndrome.
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TLDR
This continuing education activity is intended for physicians and nurses with an interest in skin and wound care to enhance the learner's competence in caring for patients with lipedema through understanding the differential diagnoses, pathophysiology, and treatment/management options.Abstract:
Purpose To enhance the learner's competence in caring for patients with lipedema through understanding the differential diagnoses, pathophysiology, and treatment/management options. Target audience This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. Objectives After participating in this educational activity, the participant should be better able to: 1. Differentiate lipedema from other similar diagnoses. 2. Tell patients with lipedema and their caregivers about treatment of this condition. 3. Construct assessments, treatment plans, and management options for patients with lipedema.read more
Citations
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Journal ArticleDOI
Rare adipose disorders (RADs) masquerading as obesity
TL;DR: In this article, lymphatic decongestive therapy, medications and supplements are recommended to reduce the abnormal subcutaneous adipose tissue (SAT) of rare adipose disorders.
Journal ArticleDOI
Lipedema: an overview of its clinical manifestations, diagnosis and treatment of the disproportional fatty deposition syndrome - systematic review.
TL;DR: Early diagnosis and treatment are mandatory for this disorder otherwise gradual enlargement of fatty deposition causes impaired mobility and further comorbidities like arthrosis and lymphatic insufficiency.
Journal Article
Diagnosis and treatment of primary lymphedema. Consensus document of the International Union of Phlebology (IUP)-2013.
Byung-Boong Lee,Mauro Andrade,Pier Luigi Antignani,F. Boccardo,N Bunke,C. Campisi,R. Damstra,Mieke Flour,I. Forner-Cordero,Peter Gloviczki,James Laredo,Hugo Partsch,Neil Piller,S Michelini,Peter S. Mortimer,Eberhard Rabe,Stanley G. Rockson,A Scuderi,Győző Szolnoky,J L Villavicencio +19 more
TL;DR: Treatment in the maintenance phase should include compression garments, self-management, including self-massage, meticulous personal hygiene and skin care, in addition to lymphtransport-promoting excercises and activities, and, if desired, pneumatic compression therapy applied in the home.
Journal ArticleDOI
Tumescent liposuction in lipoedema yields good long-term results.
TL;DR: Surgical therapy with tumescent liposuction is used for about 10 years in women with circumscribed increased subcutaneous fatty tissue, oedema, pain and bruising.
Journal ArticleDOI
Skin changes in the obese patient.
TL;DR: The effect of obesity on the skin is reviewed, including how increased body mass index affects skin physiology, skin barrier, collagen structure, and wound healing.
References
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Journal ArticleDOI
Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
Journal ArticleDOI
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Saverio Cinti,Grant A. Mitchell,Giorgio Barbatelli,Incoronata Murano,Enzo Ceresi,Emanuela Faloia,Shupei Wang,Mélanie Fortier,Andrew S. Greenberg,Martin S. Obin +9 more
TL;DR: It is demonstrated that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that sequester and scavenge the residual “free” adipocyte lipid droplet and ultimately form multinucleate giant cells, a hallmark of chronic inflammation.
Journal ArticleDOI
Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index
Dympna Gallagher,Steven B. Heymsfield,Moonseong Heo,Susan A. Jebb,Peter R. Murgatroyd,Yoichi Sakamoto +5 more
TL;DR: This proposed approach and initial findings provide the groundwork and stimulus for establishing international healthy body fat ranges.
Journal ArticleDOI
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Naomi Hosogai,Atsunori Fukuhara,Kazuya Oshima,Yugo Miyata,Sachiyo Tanaka,Katsumori Segawa,Shigetada Furukawa,Yoshihiro Tochino,Ryutaro Komuro,Morihiro Matsuda,Iichiro Shimomura +10 more
TL;DR: It is shown that adipose tissue of obese mice is hypoxic and that local adipose tissues hypoxia dysregulates the production of adipocytokines, and the results suggest that hypoperfusion and Hypoxia in adipose organs underlie the dysregulated production of fat-derived secretory factors and metabolic syndrome in obesity.