Journal ArticleDOI
Lipedema: an overview of its clinical manifestations, diagnosis and treatment of the disproportional fatty deposition syndrome - systematic review.
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TLDR
Early diagnosis and treatment are mandatory for this disorder otherwise gradual enlargement of fatty deposition causes impaired mobility and further comorbidities like arthrosis and lymphatic insufficiency.Abstract:
Lipedema is a disproportionate, symmetrical fatty swelling characterized by pain and bruising existing almost exclusively among women. We undertook a systematic review of the available literature about lipedema, given the lack of knowledge and little evidence about this disorder especially among obesity experts. Diagnosis of lipedema is usually based on clinical features. Symmetrical edema in the lower limbs with fatty deposits located to hips and thighs usually appears at puberty and often affects several members of the same family. Main disorders considered for differential diagnosis are lymphedema, obesity, lipohypertrophy and phlebedema. Treatment protocols comprise conservative (decongestive lymphatic therapy) and surgical (liposuction) approaches. Early diagnosis and treatment are mandatory for this disorder otherwise gradual enlargement of fatty deposition causes impaired mobility and further comorbidities like arthrosis and lymphatic insufficiency.read more
Citations
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Journal ArticleDOI
New Insights on Lipedema: The Enigmatic Disease of the Peripheral Fat
Anna-Theresa Bauer,Dominik von Lukowicz,Katrin Lossagk,Matthias M. Aitzetmueller,Philipp Moog,Michael Cerny,Holger Erne,Daniel Schmauss,Dominik Duscher,Hans-Guenther Machens +9 more
TL;DR: Quality of life increases significantly after surgery with a reduction of pain and swelling and decreased tendency to easy bruising, and the low prevalence of diabetes, dyslipidemia, and hypertension appears to be a specific characteristic distinguishing lipedema from lifestyle-induced obesity.
Journal ArticleDOI
Standard of care for lipedema in the United States.
Karen L. Herbst,Linda Anne Kahn,Emily Iker,Chuck Ehrlich,Thomas F Wright,Lindy McHutchison,Jaime Schwartz,Molly Sleigh,Paula M C Donahue,Kathleen H. Lisson,Tami Faris,Janis Miller,Erik Lontok,Michael S. Schwartz,Steven M Dean,John R. Bartholomew,Polly Armour,Margarita Correa-Perez,Nicholas Pennings,Edely L Wallace,Ethan Larson +20 more
TL;DR: Lipedema is a loose connective tissue disease predominantly in women identified by increased nodular and fibrotic adipose tissue on the buttocks, hips and limbs that develops at times of...
Journal ArticleDOI
Lipedema in patients after bariatric surgery.
Journal ArticleDOI
Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema.
Sandro Michelini,Pietro Chiurazzi,Valerio Marino,Daniele Dell'Orco,Elena Manara,Mirko Baglivo,Alessandro Fiorentino,Paolo Enrico Maltese,Michele Pinelli,Karen L. Herbst,Astrit Dautaj,Matteo Bertelli +11 more
TL;DR: The results suggest that AKR1C1 is the first candidate gene associated with nonsyndromic lipedema, and Comparative molecular dynamics simulations of the wild-type vs. variant enzyme suggest a partial loss-of-function of the variant.
Journal ArticleDOI
The effect of lipedema on health-related quality of life and psychological status: a narrative review of the literature.
Nuha Alwardat,Laura Di Renzo,Mohammad Alwardat,Lorenzo Romano,Gemma Lou De Santis,Paola Gualtieri,Elena Carrano,Petronilla Nocerino,Antonino De Lorenzo +8 more
TL;DR: This narrative review of the literature found that pain and tenderness are a more common and dominant characteristic in patients with lipedema and validated and adapted measures of HRQOL and psychological status for patients withlipedema are required.
References
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International statistical classification of diseases and related health problems. Tenth revision.
TL;DR: It is proposed that the chapters on external causes of injury and poisoning, and factors influencing health status and contact with health services, should form an integral part of ICD-10, for the first time in its history based on an alphanumeric coding scheme.
Journal Article
Indications for compression therapy in venous and lymphatic disease consensus based on experimental data and scientific evidence. Under the auspices of the IUP.
Hugo Partsch,Flour M,Smith Pc +2 more
TL;DR: It is shown that whilst good evidence for the use of compression is available in some clinical indications, there is much still to be discovered.
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Differential diagnosis, investigation, and current treatment of lower limb lymphedema
TL;DR: The common differential diagnosis in Western patients with lower limb swelling is secondary lymphedema, venous disease, lipedema, and adverse reaction to ipsilateral limb surgery.
Journal ArticleDOI
Lipedema: an inherited condition.
Anne H. Child,Kristiana Gordon,Pip Sharpe,Glen Brice,Pia Ostergaard,Steve Jeffery,Peter S. Mortimer +6 more
TL;DR: It is proposed that lipedema is a genetic condition with either X‐linked dominant inheritance or more likely, autosomal dominant inheritance with sex limitation, and appears to be a condition almost exclusively affecting females, presumably estrogen‐requiring as it usually manifests at puberty.