Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases.
Jose Navarro-Partida,Carlos Rodrigo Castro-Castaneda,Francisco J Santa Cruz-Pavlovich,Luis Abraham Aceves-Franco,Tomer Ori Guy,Arturo Santos +5 more
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TLDR
In this article, a review of lipid-based nanocarriers used in topical ophthalmic formulations for intraocular drug delivery is presented, including proteins, peptides and genetic material.Abstract:
Effective drug delivery to intraocular tissues remains a great challenge due to complex anatomical and physiological barriers that selectively limit the entry of drugs into the eye. To overcome these challenges, frequent topical application and regular intravitreal injections are currently used to achieve the desired drug concentrations into the eye. However, the repetitive installation or recurrent injections may result in several side effects. Recent advancements in the field of nanoparticle-based drug delivery have demonstrated promising results for topical ophthalmic nanotherapies in the treatment of intraocular diseases. Studies have revealed that nanocarriers enhance the intraocular half-life and bioavailability of several therapies including proteins, peptides and genetic material. Amongst the array of nanoparticles available nowadays, lipid-based nanosystems have shown an increased efficiency and feasibility in topical formulations, making them an important target for constant and thorough research in both preclinical and clinical practice. In this review, we will cover the promising lipid-based nanocarriers used in topical ophthalmic formulations for intraocular drug delivery.read more
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Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye
Alexander Vaneev,Alexander Vaneev,Victoria E. Tikhomirova,N.B. Chesnokova,E. N. Popova,O.V. Beznos,Olga A. Kost,Natalia L. Klyachko,Natalia L. Klyachko,Natalia L. Klyachko +9 more
TL;DR: In this article, a review of nanoparticles and nanomicelles for topical drug delivery is presented, focusing on the different drug carriers, such as synthetic and natural polymers, as well as inorganic carriers, with special attention to nanoparticles.
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TL;DR: In this paper, the authors incorporated lactoferrin into hyaluronic acid-coated liposomes by the lipid film method, followed by high pressure homogenization.
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Nutraceuticals: A Promising Therapeutic Approach in Ophthalmology
Carlos Rodrigo Castro-Castaneda,Francisco Altamirano-Lamarque,Alan Gabriel Ortega-Macías,Francisco J. Santa Cruz-Pavlovich,Alejandro Gonzalez-De la Rosa,Juan Armendáriz-Borunda,Arturo Santos,Jose Navarro-Partida +7 more
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