Journal ArticleDOI
Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems.
Reads0
Chats0
TLDR
A simple classification system for lipid formulations, based on the polarity of the blend and reviewed here, will help comparison of data between laboratories and priorities for future work are discussed.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2000-10-01. It has received 1094 citations till now. The article focuses on the topics: Drug delivery & Dosage form.read more
Citations
More filters
Journal ArticleDOI
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
TL;DR: The mechanisms by which lipids and lipidic excipients affect the oral absorption of lipophilic drugs are detailed and a perspective on the possible future applications of lipid-based delivery systems is provided.
Journal ArticleDOI
"Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era.
Ae Jung Huh,Young Jik Kwon +1 more
TL;DR: This review summarizes emerging efforts in combating against infectious diseases, particularly using antimicrobial NPs and antibiotics delivery systems as new tools to tackle the current challenges in treating infectious diseases.
Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
Nanoemulsions versus microemulsions: terminology, differences, and similarities
TL;DR: In this article, the differences and similarities between nanoemulsions and micro-mulsions in terms of their compositions, structure, fabrication, properties, and stability are discussed.
Journal ArticleDOI
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Neslihan Gürsoy,Simon Benita +1 more
TL;DR: Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds as discussed by the authors.
References
More filters
Journal ArticleDOI
Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects
TL;DR: This review highlights the state-of-the-art in pharmaceutical microemulsions with emphasis on self-emulsifying systems, from both a physical and biopharmaceutical perspective, primarily focused on their potential for oral drug delivery and intestinal absorption improvement.
Journal ArticleDOI
Formulation of self-emulsifying drug delivery systems
TL;DR: Self-emulsifying drug delivery systems (SEDDS) are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal tract as discussed by the authors.
Journal ArticleDOI
Lipid-based vehicles for the oral delivery of poorly water soluble drugs
TL;DR: This review attempts to provide a framework for the assessment of lipid based formulations by describing how aspects of GI physiology, and the choice of lipids and their formulation attributes, impact on dose form performance.
Journal ArticleDOI
Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs.
Tatyana Gershanik,Simon Benita +1 more
TL;DR: This review outlines SDLFs as one of the most promising approaches to overcome the formulation difficulties of these hydrophobic/lipophilic drugs.
Journal ArticleDOI
Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound.
Susan A. Charman,William N. Charman,Mark Rogge,Terry D. Wilson,Frank J. Dutko,Colin W. Pouton +5 more
TL;DR: Self-emulsifying drug delivery systems (SEDDSs) represent a possible alternative to traditional oral formulations of lipophilic compounds and improved the reproducibility of the plasma profile in terms of the maximum plasma concentration (Cmax) and the time to reach the maximum concentration (tmax).
Related Papers (5)
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Neslihan Gürsoy,Simon Benita +1 more