Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation
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1,056 citations
Cites background from "Live imaging of astrocyte responses..."
...become reactive and hypertrophy and in some cases proliferate (Bardehle et al., 2013; Zheng et al., 2010)....
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...…in situ and do not migrate either to or away from injury sites but can swell osmotically and, depending on the severity of injury or ischemia, can die in the center of severe lesions or can become reactive and hypertrophy and in some cases proliferate (Bardehle et al., 2013; Zheng et al., 2010)....
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Cites background or result from "Live imaging of astrocyte responses..."
...Most astrocytes in the injured cortex become hypertrophic, upregulate GFAP, but stay within their tiled domains with only a limited overlap between domains of neighboring astrocytes (16, 260), while subsets of astrocytes become polarized or proliferate, the latter typically found in close association with blood vessels (16)....
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...Astrocyte polarity and directional migration seem to play a crucial role in astrocyte ability to react to injury: astrocytes depleted of the small RhoGTPase Cdc42, a key regulator of cell polarization, show impaired recruitment to the stab wound lesion despite their upregulation of GFAP and hypertrophic response (192)....
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...Similarly, selective ablation of the small RhoGTPase Cdc42 in astrocytes impaired their recruitment to the stab wound lesion and was accompanied by higher density of microglia in the lesion (192)....
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...It was proposed that these proliferating blood vessel-associated astrocytes regulate migration and proliferation of glial scar forming pericytes (16, 82)....
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...The proliferative response of astrocytes after injury seems to be specific for astrocytes in the juxtavascular space and depends only partially on Cdc42 (16)....
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585 citations
Cites result from "Live imaging of astrocyte responses..."
...It deserves mention that this organization occurred without obvious evidence for long distance migration, similar to reports using different transgenic analyses or in vivo imaging to show local derivation and minimal migration of newly generated reactive astroglia after CNS injury (Tsai et al., 2012; Bardehle et al., 2013)....
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...…organization occurred without obvious evidence for long distance migration, similar to reports using different transgenic analyses or in vivo imaging to show local derivation and minimal migration of newly generated reactive astroglia after CNS injury (Tsai et al., 2012; Bardehle et al., 2013)....
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...4 – 6) without long distance migration, in a manner compatible with reports by others using different types of transgenic analyses or in vivo imaging (Tsai et al., 2012; Bardehle et al., 2013)....
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References
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