Liver sympathetic denervation reverses obesity-induced hepatic steatosis
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...Selective hepatic sympathetic denervation using phenol also resulted in similar impact on hepatic gluconeogenic enzymes and led to almost complete resolution of hepatic steatosis in 1 week (40)....
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...Whole body chemical sympathectomy lowered hepatic expression of gluconeogenic enzymes and peroxisome proliferator activated receptor (PPAR) alpha (40)....
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...did not affect mitochondrial or peroxiosomal β-oxidation of fatty acids (40)....
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References
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"Liver sympathetic denervation rever..." refers background in this paper
...Non-alcoholic fatty liver disease (NAFLD) affects approximately 30% of the US population and is now the primary cause of liver transplants (Angulo, 2002)....
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...Similarly, removal of the liver sympathetic nerves did not alter hepatic expression of microsomal triglyceride transfer protein (MTTP), an endoplasmic reticulum protein involved in the processing of VLDL particles (Fig....
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...NAFLD is a direct result of hepatic steatosis (Angulo, 2002; Jou et al. 2008), which can progress to non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma (Jou et al....
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...Hepatic lipid accumulation is determined by a complex interplay between de novo lipogenesis, hepatic β-oxidation, free fatty acid (FFA) uptake and triglyceride disposal from the liver in the form of very low-density lipoprotein (VLDL) (Angulo, 2002; Jou et al. 2008; Vernon et al. 2011)....
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...In this context, numerous hormonal and nutritional factors have been linked to altered hepatic lipid homeostasis (Angulo, 2002; Jou et al. 2008)....
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2,870 citations
"Liver sympathetic denervation rever..." refers background in this paper
...Previous findings indicate that 60% of hepatic triglycerides are derived from plasma non-esterified FFAs (Donnelly et al. 2005), which are taken up by hepatocyte cell membrane transporters, including cluster of differentiation 36 (CD36) (Coburn et al. 2000) and fatty acid transport proteins (FATPs) (Doege et al. 2006)....
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...Liver triglycerides are also synthesized from glucose via de novo lipogenesis, with this pathway contributing to 25% of the total hepatic triglyceride pool in NAFLD individuals (Donnelly et al. 2005; Lambert et al. 2014)....
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...Pparα expression, which is involved, in part, in the regulation of FFA uptake in response to elevated FFAs (Schoonjans et al. 1997), was also elevated in the liver of obese mice when compared with normal chow controls (Fig....
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...Previous findings indicate that 60% of hepatic triglycerides are derived from plasma non-esterified FFAs (Donnelly et al. 2005), which are taken up by hepatocyte cell membrane transporters, including cluster of differentiation 36 (CD36) (Coburn et al....
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...Previous findings indicate that 60% of hepatic triglycerides are derived from plasma non-esterified FFAs (Donnelly et al. 2005), which are taken up by hepatocyte cell membrane transporters, including cluster of differentiation 36 (CD36) (Coburn et al. 2000) and fatty acid transport proteins (FATPs)…...
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2,679 citations
"Liver sympathetic denervation rever..." refers background in this paper
...Similarly, removal of the liver sympathetic nerves did not alter hepatic expression of microsomal triglyceride transfer protein (MTTP), an endoplasmic reticulum protein involved in the processing of VLDL particles (Fig....
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...Hepatic lipid accumulation is determined by a complex interplay between de novo lipogenesis, hepatic β-oxidation, free fatty acid (FFA) uptake and triglyceride disposal from the liver in the form of very low-density lipoprotein (VLDL) (Angulo, 2002; Jou et al. 2008; Vernon et al. 2011)....
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...To date, most studies have taken a ‘liver-centric’ (or adipose tissue) view to delineate cellular and molecular mechanisms contributing to NAFLD (Lewis et al. 2002; Postic & Girard, 2008; Vernon et al. 2011)....
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...A limited number of observations implicate sympathetic outflow to the liver in lipid metabolism, VLDL processing and modulation of glucose metabolism (Carreno & Seelaender, 2004; Dicostanzo et al. 2006; Bruinstroop et al. 2015; Kandilis et al. 2015)....
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...Thus, factors that lead to an imbalance between lipid acquisition (FFA uptake and de novo lipogenesis) and disposal (β-oxidation and VLDL export) can contribute to the development of hepatic steatosis....
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1,571 citations
"Liver sympathetic denervation rever..." refers background in this paper
...Central control of sympathetic outflow is determined by a complex interplay between circulating factors that act upon the brain, afferent inputs, and integration of neural signals from higher order autonomic CNS networks (Loewy & Spyer, 1990; Dampney, 1994)....
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