LncRNA CASC2 Interacts With miR-181a to Modulate Glioma Growth and Resistance to TMZ Through PTEN Pathway.
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...5B), supporting the negative regulation of PTEN by lncARSR. lncARSR ACTIVATES PI3K/Akt PATHWAY PTEN is known to negatively regulate PI3K/Akt pathway and further inhibit tumor progression [Liao et al., 2017; Miao et al., 2017]....
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...lncARSR ACTIVATES PI3K/Akt PATHWAY PTEN is known to negatively regulate PI3K/Akt pathway and further inhibit tumor progression [Liao et al., 2017; Miao et al., 2017]....
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93 citations
Cites background from "LncRNA CASC2 Interacts With miR-181..."
...The elevated expression of miR-181a is associated with lncRNA CASC2 and modulates the resistance to TMZ [44]....
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...Their data shows that the expression of CASC2 influenced the TMZ resistance through the CASC2/miR181a/PTEN pathway [44]....
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...CASC2 also induces chemoresistance by down-regulating the miR-181a/PTEN pathway [44]....
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...miR-181a PTEN pathway LGG-30, HGG-27 Proliferation, chemoresistance to TMZ [44]...
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References
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"LncRNA CASC2 Interacts With miR-181..." refers background in this paper
...Emerging evidence has regarded lncRNAs as major regulators of normal development and diseases, including cancer [Ponting et al., 2009]....
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"LncRNA CASC2 Interacts With miR-181..." refers background in this paper
...Human genome sequence data indicate that more than 90% of the DNA sequences actively transcribed, but only 2% of it encodes protein, so most of the transcripts are referred to as non-coding RNAs (ncRNAs) [Djebali et al., 2012; Martens-Uzunova et al., 2014]....
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296 citations
"LncRNA CASC2 Interacts With miR-181..." refers background in this paper
...Another lncRNA, UCA1, enhances 5-fluorouracil resistance in colorectal cancer by inhibiting miR204-5p [Bian et al., 2016]....
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