Journal ArticleDOI
Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model
Manuel Feinauer,Manuel Feinauer,Stefan W. Schneider,Anna S. Berghoff,Anna S. Berghoff,Anna S. Berghoff,Jose Ramon Robador,Cedric Tehranian,Cedric Tehranian,Matthia A. Karreman,Matthia A. Karreman,Varun Venkataramani,Varun Venkataramani,Varun Venkataramani,Gergely Solecki,Gergely Solecki,Gergely Solecki,Julia Grosch,Julia Grosch,Katharina Gunkel,Katharina Gunkel,Bogdana Kovalchuk,Bogdana Kovalchuk,Frank Thomas Mayer,Manuel Fischer,Michael O. Breckwoldt,Maik Brune,Yannik Schwab,Wolfgang Wick,Wolfgang Wick,Alexander Bauer,Frank Winkler,Frank Winkler +32 more
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TLDR
In vivo multiphoton laser-scanning microscopy of the entire brain metastatic cascade allowed unprecedented insights into how blood clot formation and von Willebrand factor deposition determine the arrest of circulating cancer cells and subsequent brain colonization in mice, discovering a novel and specific mechanism that is crucial for brain colonization.About:
This article is published in Blood.The article was published on 2021-03-04. It has received 27 citations till now. The article focuses on the topics: Brain metastasis & Cancer.read more
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The Manifold Cellular Functions of von Willebrand Factor.
Angelika Mojzisch,Maria A. Brehm +1 more
TL;DR: The plasma glycoprotein von Willebrand factor (VWF) is exclusively synthesized in endothelial cells (ECs) and megakaryocytes, the precursor cells of platelets as discussed by the authors.
Journal ArticleDOI
Breast cancer cells mediate endothelial cell activation, promoting von Willebrand factor release, tumor adhesion, and transendothelial migration
Sukhraj Pal Singh Dhami,Sean Patmore,Claire Comerford,Ciaran Byrne,Brenton Cavanagh,John C. Castle,Cliona C. Kirwan,Martin Kenny,Ingmar Schoen,James S. O’Donnell,Jamie M. O’Sullivan +10 more
TL;DR: In a model of melanoma, treatment with low molecular weight heparin (LMWH) negatively regulated VWF secretion and attenuated tumor metastasis, and elevated plasma VWF levels constitute an independent biomarker for VTE risk.
Journal ArticleDOI
Circulating tumor cell-blood cell crosstalk: Biology and clinical relevance.
TL;DR: In this article , the potential clinical relevance of these interactions as biomarkers or as targets for anti-metastatic therapies was discussed, as well as potential clinical significance of the interactions between CTCs and different hematopoietic cells.
The microenvironment of brain metastases from solid tumors.
TL;DR: In this paper, the authors discuss unique aspects of the TME in the context of brain metastases and pathways through which they may hold the key to the discovery of new and effective therapies for patients with brain metastasis.
Journal ArticleDOI
Tumor Immune Microenvironment of Brain Metastases: Toward Unlocking Antitumor Immunity
TL;DR: In this article , the role of glial cells in the central nervous system immune response to brain metastasis is discussed. But the authors do not discuss the clinical landscape of ICI activity in the CNS and CNS immunobiology.
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Brain tumour cells interconnect to a functional and resistant network
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TL;DR: It is shown that many tumour cells in astrocytomas extend ultra-long membrane protrusions, and use these distinct tumour microtubes as routes for brain invasion, proliferation, and to interconnect over long distances, which develops functional multicellular network structures.