Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure.
Hirofumi Yasue,Michihiro Yoshimura,Hitoshi Sumida,Koichi Kikuta,Kiyotaka Kugiyama,Michihisa Jougasaki,Hisao Ogawa,Ken Okumura,Masashi Mukoyama,Kazuwa Nakao +9 more
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TLDR
Examination of the sources and mechanisms of the secretion of BNP in comparison with those of ANP in control subjects and in patients with heart failure concludes that BNP is secreted mainly from the left ventricle in normal adult humans as well as in Patients with left ventricular dysfunction.Abstract:
BACKGROUNDB-type or brain natriuretic peptide (BNP) is a novel natriuretic peptide secreted from the heart that forms a peptide family with A-type or atrial natriuretic peptide (ANP), and its plasma level has been shown to be increased in patients with congestive heart failure. This study was designed to examine the sources and mechanisms of the secretion of BNP in comparison with those of ANP in control subjects and in patients with heart failure.METHODS AND RESULTSWe measured the plasma levels of BNP as well as ANP in 16 patients with dilated cardiomyopathy (11 men and 5 women; mean age, 59 years) and 18 control subjects (9 men and 9 women; mean age, 54 years) by sampling blood from the femoral vein, the aortic root, the anterior interventricular vein (AIV), and the coronary sinus using the newly developed immunoradiometric assay systems. In the control subjects, there was no significant difference in the plasma ANP level between the aortic root and the AIV (24.0 +/- 5.2 pg/mL versus 32.2 +/- 17.0 pg/mL...read more
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Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.
Alan S. Maisel,Padma Krishnaswamy,Richard M. Nowak,James McCord,Judd E. Hollander,Philippe Duc,Torbjørn Omland,Alan B. Storrow,William T. Abraham,Alan H.B. Wu,Paul Clopton,Philippe Gabriel Steg,Arne Westheim,Catherine W. Knudsen,Alberto Perez,Radmila Kazanegra,Howard C. Herrmann,Peter A. McCullough +17 more
TL;DR: Used in conjunction with other clinical information, rapid measurement of B-type natriuretic peptide is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.
Journal ArticleDOI
Cardiovascular Risk Factors and Excess Adiposity Among Overweight Children and Adolescents: The Bogalusa Heart Study
TL;DR: The 99th P of BMI-for-age may be appropriate for identifying children who are at very high risk for biochemical abnormalities and severe adult obesity.
Journal ArticleDOI
Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations.
Richard W. Troughton,Chris Frampton,Timothy G. Yandle,Eric A Espine,M. Gary Nicholls,A. Mark Richards +5 more
TL;DR: N-BNP-guided treatment of heart failure reduced total cardiovascular events, delayed time to first event compared with intensive clinically guided treatment, and changed left-ventricular function, quality of life, renal function, and adverse events were similar in both groups.
Journal ArticleDOI
The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes.
James A. de Lemos,David A. Morrow,Jane H. Bentley,Torbjørn Omland,Marc S. Sabatine,Carolyn H. McCabe,Christian Hall,Christopher P. Cannon,Eugene Braunwald +8 more
TL;DR: A single measurement of B-type natriuretic peptide, obtained in the first few days after the onset of ischemic symptoms, provides powerful information for use in risk stratification across the spectrum of acute coronary syndromes, and suggests that cardiac neurohormonal activation may be a unifying feature among patients at high risk for death after acute coronary syndrome.
Journal ArticleDOI
B-type natriuretic peptide in cardiovascular disease
TL;DR: Measurement of circulating concentrations of B-type natriuretic peptide and the N-terminal fragment of its prohormones and use of recombinant human BNP (nesiritide) and vasopeptidase inhibitors to treat heart failure are focused on.
References
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Journal ArticleDOI
A new natriuretic peptide in porcine brain
TL;DR: The brain natriuretic peptide (BNP) as mentioned in this paper was identified in porcine brain of a novel peptide of 26 amino acid residues, eliciting a pharmacological spectrum very similar to that of ANP.
Journal ArticleDOI
Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.
Masashi Mukoyama,Kazumasa Nakao,Kiminori Hosoda,Shin Ichi Suga,Yoshihiko Saito,Yoshihiro Ogawa,Gotaro Shirakami,Michihisa Jougasaki,K Obata,Hirofumi Yasue +9 more
TL;DR: Results indicate that BNP is a novel cardiac hormone secreted predominantly from the ventricle, and that the synthesis, secretion and clearance of BNP differ from those of ANP, suggesting discrete physiological and pathophysiological roles of HBNP in a dual natriuretic peptide system.
Journal ArticleDOI
Atrial natriuretic factor: a hormone produced by the heart
TL;DR: This hormone, described in 1981 as atrial natriuretic factor (ANF), is diuretic, hypotensive, and has an inhibitory effect on renin and aldosterone secretion.
Journal ArticleDOI
Atrial Natriuretic Peptide Elevation in Congestive Heart Failure in the Human
John C. Burnett,P. C. Kao,DC Hu,D.W. Heser,D Heublein,Joey P. Granger,T. J. Opgenorth,GS Reeder +7 more
TL;DR: It is established that elevated cardiac filling pressure is associated with increased circulating concentrations of atrial natriuretic peptide and that congestive heart failure is not characterized by a deficiency in atrialNatriureic peptide, but with its elevation.
Journal ArticleDOI
Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.
Robert J. Cody,Steven A. Atlas,John H. Laragh,S H Kubo,Andrew B. Covit,K. S. Ryman,A. Shaknovich,K Pondolfino,M Clark,M J Camargo +9 more
TL;DR: The authors investigated atrial natriuretic factor (ANF) in humans, measuring plasma immunoreactive (ir) ANF, and renal, hormonal, and hemodynamic responses to ANF infusion, in normal subjects (NL) and congestive heart failure patients (CHF).
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