Journal ArticleDOI
Location of Proliferating Cells in Human Epidermis
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TLDR
A significant number of thymidine-labeled cells (deoxyribonucleic acid-synthesizing cells) were found above the basal cell layer in all conditions examined.Abstract:
The location of the proliferative pool of cells in normal epidermis, ichthyosis vulgaris, lamellar ichthyosis, X-linked ichthyosis, epidermolytic hyperkeratosis, and psoriasis was examined using autoradiographic and projection techniques. A significant number of thymidine-labeled cells (deoxyribonucleic acid-synthesizing cells) were found above the basal cell layer in all conditions examined. Cell proliferation in the epidermis is not limited to the basal layer but also occurs in more superficial cells.read more
Citations
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Journal ArticleDOI
Location of stem cells of human hair follicles by clonal analysis
TL;DR: The hair follicle, like the epidermis, contains keratinocytes with the expected property of stem cells: an extensive proliferative capacity permitting the generation of a large amount of epithelium.
Journal ArticleDOI
Epidermal stem cells: markers, patterning and the control of stem cell fate.
TL;DR: Variation in the levels of E-cadherin, beta-catenin and plakoglobin within the basal layer suggests that stem cells may also differ from transit amplifying cells in intercellular adhesiveness.
Journal ArticleDOI
Heterogeneity in epidermal basal keratinocytes: morphological and functional correlations
Robert M. Lavker,Tung-Tien Sun +1 more
TL;DR: Two structurally distinct populations of basal keratinocytes, nonserrated and serrated, were observed in cynomolgus monkey and human palm epidermis, and it is suggested that these cells represent a stem cell population and that serrated cells help anchor the epidermal dermis to the dermis.
Journal ArticleDOI
Epidermal stem cells.
Robert M. Lavker,Tung-Tien Sun +1 more
TL;DR: Findings are consistent with the concept that the nonserrated basal keratinocytes may represent stem cells that give rise to suprabasally located, transient amplifying cells before undergoing terminal differentiation in monkey palm epidermal stem cells.
Journal ArticleDOI
The Skin: Its Structure and Response to Ionizing Radiation
TL;DR: The structural organization of human skin is described and compared with that of the pig, with which it shows many similarities, in order that the response of the skin to ionizing radiation may be more fully understood.
References
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Journal ArticleDOI
Examination of the Epidermis by the Strip Method
TL;DR: The basic thesis that all epidermal cells are derived from the basal cells is defended, even though the prickle cells-the differentiating intermitotics-boost the total number of cells available for kera-tinization and desquamation.
Journal ArticleDOI
Kinetics of Hyperplasia in Psoriasis
E. J. Van Scott,Thomas M. Ekel +1 more
TL;DR: This study attempts to characterize the hyperplasia of the epidermis in psoriasis, and to outline the kinetics of some of the changes in the tissues and cell populations involved.
Journal ArticleDOI
Abnormal cell proliferation in psoriasis.
TL;DR: The present study was undertaken to determine whether the cell cycle of individual germinative cells is faster in psoriatic epidermis than normal and if such an acceleration is a significant factor in the pathophysiology of psoriasis.
Journal Article
The relationship of the cell cycle to tumor growth and control of cell division: a review.
TL;DR: Although the length of the cell cycle varies in different kinds of cells, it is shorter in certain cells of the adult animal than in some of the fastest growing tumors, so tumor growth must involve other kinetic parameters besides speed of cell proliferation.
Journal ArticleDOI
Autoradiographic analysis of turnover times of normal and psoriatic epidermis.
TL;DR: A turnover time of approximately 30 days of pig epidermis was recently found by Weinstein (3) in an autoradiographic study utilizing both tritiated thymidine and glycine-C14 as nuclear and protein labels respectively.