Journal ArticleDOI
Long-term depression in the CNS
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TLDR
Converging evidence supports a crucial role of LTD in some types of learning and memory and in situations in which cognitive demands require a flexible response.Abstract:
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various pathological conditions. Several mechanistically distinct forms of this type of synaptic plasticity have been identified and their molecular mechanisms are starting to be unravelled. Most studies have focused on forms of LTD that are triggered by synaptic activation of either NMDARs (N-methyl-D-aspartate receptors) or metabotropic glutamate receptors (mGluRs). Converging evidence supports a crucial role of LTD in some types of learning and memory and in situations in which cognitive demands require a flexible response. In addition, LTD may underlie the cognitive effects of acute stress, the addictive potential of some drugs of abuse and the elimination of synapses in neurodegenerative diseases.read more
Citations
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About sleep's role in memory
Bjoern Rasch,Jan Born,Jan Born +2 more
TL;DR: This review aims to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings.
Journal ArticleDOI
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
James J. Lee,Robbee Wedow,Aysu Okbay,Edward Kong,Omeed Maghzian,Meghan Zacher,Tuan Anh Nguyen-Viet,Peter Bowers,Julia Sidorenko,Julia Sidorenko,Richard Karlsson Linnér,Richard Karlsson Linnér,Mark Alan Fontana,Mark Alan Fontana,Tushar Kundu,Chanwook Lee,Hui Li,Ruoxi Li,Rebecca Royer,Pascal Timshel,Pascal Timshel,Raymond K. Walters,Raymond K. Walters,Emily A. Willoughby,Loic Yengo,Maris Alver,Yanchun Bao,David W. Clark,Felix R. Day,Nicholas A. Furlotte,Peter K. Joshi,Peter K. Joshi,Kathryn E. Kemper,Aaron Kleinman,Claudia Langenberg,Reedik Mägi,Joey W. Trampush,Shefali S. Verma,Yang Wu,Max Lam,Jing Hua Zhao,Zhili Zheng,Zhili Zheng,Jason D. Boardman,Harry Campbell,Jeremy Freese,Kathleen Mullan Harris,Caroline Hayward,Pamela Herd,Pamela Herd,Meena Kumari,Todd Lencz,Todd Lencz,Jian'an Luan,Anil K. Malhotra,Anil K. Malhotra,Andres Metspalu,Lili Milani,Ken K. Ong,John R. B. Perry,David J. Porteous,Marylyn D. Ritchie,Melissa C. Smart,Blair H. Smith,Joyce Y. Tung,Nicholas J. Wareham,James F. Wilson,Jonathan P. Beauchamp,Dalton Conley,Tõnu Esko,Steven F. Lehrer,Steven F. Lehrer,Steven F. Lehrer,Patrik K. E. Magnusson,Sven Oskarsson,Tune H. Pers,Tune H. Pers,Matthew R. Robinson,Matthew R. Robinson,Kevin Thom,Chelsea Watson,Christopher F. Chabris,Michelle N. Meyer,David Laibson,Jian Yang,Magnus Johannesson,Philipp Koellinger,Philipp Koellinger,Patrick Turley,Patrick Turley,Peter M. Visscher,Daniel J. Benjamin,Daniel J. Benjamin,David Cesarini,David Cesarini +94 more
TL;DR: A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance ineducational attainment and 7–10% ofthe variance in cognitive performance, which substantially increases the utility ofpolygenic scores as tools in research.
Journal ArticleDOI
Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration
Giulio Tononi,Chiara Cirelli +1 more
TL;DR: This Perspective considers the rationale and evidence for the synaptic homeostasis hypothesis (SHY), and points to open issues related to sleep and plasticity.
Journal ArticleDOI
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
TL;DR: Findings highlight the central importance of homeostatic control of mood circuit connections and form the basis of a synaptogenic hypothesis of depression and treatment response.
Journal ArticleDOI
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
Millan Mark,Yves Agid,Martin Brüne,Edward T. Bullmore,Cameron S. Carter,Nicola S. Clayton,Richard C. Connor,Sabrina Davis,Bill Deakin,Robert J. DeRubeis,Bruno Dubois,Mark A. Geyer,Guy M. Goodwin,Philip Gorwood,Thérèse M. Jay,Marian Joëls,Isabelle M. Mansuy,Andreas Meyer-Lindenberg,Declan G. Murphy,Edmund T. Rolls,Bernd Saletu,Michael Spedding,John A. Sweeney,Miles A. Whittington,Larry J. Young +24 more
TL;DR: This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments.
References
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Book
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Journal ArticleDOI
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