Long term immunologic consequences of experimental stroke and mucosal tolerance
Citations
1,949 citations
Cites background from "Long term immunologic consequences ..."
...Worsening in the chronic phase has also been reported in tolerization applied to models of cerebral ischemi...
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Cites background from "Long term immunologic consequences ..."
...Quite possibly T-cell activation needs to be finely tuned to yield a tolerization state, associated with protective action (103, 104), rather than an aggressive (auto)-immune response....
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Cites background from "Long term immunologic consequences ..."
...Induction of mucosal tolerance to brain antigens after middle cerebral artery occlusion (MCAO) was associated with improved outcome and a reduction in infarct volume in the hours to days after stroke onset (92–95), but this was only beneficial up to a month (96)....
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References
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Additional excerpts
...0) was inserted into the common carotid artery and advanced into the internal carotid artery [11]; 20 OVA tolerized and 25 MBP tolerized animals were subjected to MCAO....
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2,490 citations
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...Neurological status was assessed at set time points after MCAO; tests included a modification of the Bederson scale and an adaptation of the 'sticky tape test' [12,13]....
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797 citations
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...Despite the initial inflammatory response in the brain and periphery after stroke, the immune system later becomes incapable of adequately responding to pathogens, predisposing animals to infection [3]....
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...Further, the ratio of antigen specific TH17 to TH1 cells can determine the nature of the autoimmune disease [25]....
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494 citations
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...Immediately after experimental stroke, peripheral blood lymphocytes and splenocytes become activated and are capable of secreting massive amounts of proinflammatory cytokines [1]....
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