Long term immunologic consequences of experimental stroke and mucosal tolerance
Citations
20 citations
Cites background from "Long term immunologic consequences ..."
...the percentage of immunosuppressive Tregs relative to B lymphocytes may also be important (Gee et al., 2009; Offner et al., 2006b)....
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...The composition of surviving splenocytes, e.g. the percentage of immunosuppressive Tregs relative to B lymphocytes may also be important (Gee et al., 2009; Offner et al., 2006b)....
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20 citations
Cites background or result from "Long term immunologic consequences ..."
...Similar to our findings in other studies (Gee et al, 2008, 2009; Zierath et al, 2010), the data in this study show an inverse relationship between the TH1 immune response to brain antigens in the spleen and performance on the rotarod in animals subjected to 2 hours MCAO....
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...A Treg response can be induced through mucosal administration of antigen, but there are data that question the longterm safety of this strategy (Bai et al, 1998; Blanas et al, 1996; Gee et al, 2009; Genain et al, 1996; Xiao and Link, 1997)....
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20 citations
19 citations
Cites background from "Long term immunologic consequences ..."
...We previously showed that a TH1 type immune response to MBP is associated with worse outcome in experimental models of stroke (Becker et al., 2005; Gee et al., 2008; Gee et al., 2009) and that TH1 responses to MBP are associated with worse clinical outcome in a cohort of stroke patients 3 months after stroke onset (Becker et al....
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...In these experiments, a TH1(+) response to MBP was associated with worse stroke outcome (Becker et al., 2005; Gee et al., 2008, 2009)....
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19 citations
Cites background or result from "Long term immunologic consequences ..."
...And while animals with TH1(+) responses to MBP perform worse on behavioral tests after stroke, they do not manifest overt signs of experimental allergic encephalomyelitis (EAE) (Becker et al., 2005; Gee et al., 2008, 2009; Zierath et al., 2010b)....
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...These proportions are similar to what we have seen previously among animals subjected to MCAO (although the likelihood of developing a TH1 response can be increased by exposing animals to an inflammatory stimulus at the time of MCAO) (Becker et al., 2005; Gee et al., 2009; Zierath et al., 2010a, 2013)....
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References
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Additional excerpts
...0) was inserted into the common carotid artery and advanced into the internal carotid artery [11]; 20 OVA tolerized and 25 MBP tolerized animals were subjected to MCAO....
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2,490 citations
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...Neurological status was assessed at set time points after MCAO; tests included a modification of the Bederson scale and an adaptation of the 'sticky tape test' [12,13]....
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797 citations
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...Despite the initial inflammatory response in the brain and periphery after stroke, the immune system later becomes incapable of adequately responding to pathogens, predisposing animals to infection [3]....
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585 citations
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...Further, the ratio of antigen specific TH17 to TH1 cells can determine the nature of the autoimmune disease [25]....
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494 citations
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...Immediately after experimental stroke, peripheral blood lymphocytes and splenocytes become activated and are capable of secreting massive amounts of proinflammatory cytokines [1]....
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