scispace - formally typeset
Search or ask a question
Journal ArticleDOI

Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.

TL;DR: From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).
About: This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2011-01-18. It has received 212 citations till now. The article focuses on the topics: Solid lipid nanoparticle & Glyceryl behenate.
Citations
More filters
Journal ArticleDOI
TL;DR: N nanoparticle design aspects to improve delivery to particular sites in the GI tract are discussed and the state-of-the-art in preclinical targeted nanoparticles design is reviewed.

286 citations


Cites background from "Lopinavir loaded solid lipid nanopa..."

  • ...91fold higher for SLN compared to lopinavir suspension [184]....

    [...]

  • ...Alex and coworkers developed lopinavir-loaded glyceryl behenate SLN to improve oral bioavailability of lopinavir [184]....

    [...]

Journal ArticleDOI
TL;DR: This work briefly reviews up-to-date developments in solid lipid nanoparticles (SLNs) as effective nanocolloidal system for drug delivery and summarizes SLNs in terms of their preparation, surface modification and properties.

250 citations


Cites background from "Lopinavir loaded solid lipid nanopa..."

  • ...Numerous studies indicated that the intracellular delivery and bioavailability of drugs encapsulated in SLNs can be significantly enhanced [31, 87]....

    [...]

  • ...usually added to the oil phase [30-35] and rarely to the aqueous phase [27, 36]....

    [...]

  • ...The group of Souto [31] used SLNs to target intestinal lymphatic vessels in combined anticancer therapy which resulted in significant improvement of bioavailability of antiviral drug....

    [...]

Journal ArticleDOI
TL;DR: The protective effect of SLNs, coupled with their sustained/controlled release properties, prevents drugs/macromolecules from premature degradation and improves their stability in the GIT, and make SLNs a potential BA enhancer vehicle for various Class II, III and IV drugs.
Abstract: Introduction: The therapeutic efficacy of perorally administered drugs is often obscured by their poor oral bioavailability (BA) and low metabolic stability in the gastrointestinal tract (GIT). Solid lipid nanoparticles (SLNs) have emerged as potential BA enhancer vehicles for various Class II, III and IV drug molecules. Area covered: This review examines the recent advancements in SLN technology, with regards to oral drug delivery. The discussion critically examines the effect of various key constituents on SLN absorption and their applications in oral drug delivery. The relationship between the complexity of absorption (and various factors involved during absorption, including particle size), stability and the self-emulsifying ability of the lipids used has been explored. Expert opinion: The protective effect of SLNs, coupled with their sustained/controlled release properties, prevents drugs/macromolecules from premature degradation and improves their stability in the GIT. An extensive literature survey...

226 citations

Journal ArticleDOI
TL;DR: This review highlights the simple and easily scaled-up novel SLN and NLC along with their different production techniques, hurdles, and strategies for the production of LNs, characterization, lyophilization and drug release and summarizes the research findings reported by the different researchers regarding the different method of preparation, excipients and their significant findings.

223 citations

Journal ArticleDOI
TL;DR: Although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.
Abstract: Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal carriers, nanolipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) are ideal delivery systems with the advantages of biodegradation and nontoxicity. Among them, nano-structured lipid carriers and solid lipid nanoparticles (SLNs) are dominant, which can be modified to exhibit various advantages, compared to liposomes and polymeric nanoparticles. Nano-structured lipid carriers and SLNs are non-biotoxic since they are biodegradable. Besides, they are highly stable. Their (nano-structured lipid carriers and SLNs) morphology, structural characteristics, ingredients used for preparation, techniques for their production, and characterization using various methods are discussed in this review. Also, although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.

222 citations

References
More filters
Book ChapterDOI
17 Jul 2019
TL;DR: In this paper, the authors proposed a method to solve the problem of spamming: http://www.webpages.com.augmentedrome.com/webpages/
Abstract: (Internet)

1,833 citations

Journal ArticleDOI
TL;DR: The success and limitations of a formulation approach using lipid-based vehicles are analyzed, potential areas for further research are highlighted and a deeper appreciation of all the mechanisms is still unrealized.

376 citations

Journal ArticleDOI
TL;DR: The mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport are described, directed toward recent advances in understanding regarding the impact of lipid source and intracellular lipid trafficking pathways.

365 citations

Journal ArticleDOI
TL;DR: SLN are suitable drug delivery system for the improvement of bioavailability of lipophilic drugs such as clozapine and in tested organs, the AUC and MRT of clozAPine SLNs were higher than those of clazapine suspension especially in brain and reticuloendothelial cell-containing organs.

353 citations

Journal ArticleDOI
TL;DR: This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery using high-pressure homogenization production methods.
Abstract: Solid lipid nanoparticles (SLN®), nanostructured lipid carriers (NLC®), and lipid–drug conjugates (LDC®), commonly produced by high-pressure homogenization, are interesting vectors for oral delivery of lipophilic and, to a certain extent, hydrophilic substances. Their production can be done without the use of organic solvents. Techniques to make them a physically stable delivery system have been developed. Scaling up of the production process from lab-size to large-scale dimensions using high-pressure homogenization can be easily achieved by using a different type of homogenizer. The machines used for large-scale production often yield an even better product quality than the lab-scale types. This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery. It focuses mainly on high-pressure homogenization production methods.

329 citations


"Lopinavir loaded solid lipid nanopa..." refers background in this paper

  • ...…w p b i t a a & 8 w f u a w t f 3 ( a N w s m b e w N r 3 t o c g t 1 t p r b m l a m f u u v p r a t f f fi M g s w 3 u a c p 2 M.R. Aji Alex et al. / European Journal o icroemulsions, self-emulsifying drug delivery systems and polyeric nanoparticles (Araujo et al., 2010; Muchow et al., 2008)....

    [...]