Loss of long-term depression in the insular cortex after tail amputation in adult mice
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TLDR
It is found that tail amputation in adult mice produced a selective loss of low frequency stimulation-induced LTD in the IC, without affecting (RS)-3,5-dihydroxyphenylglycine (DHPG)-evoked LTD, and it is suggested that restoration of insular LTD may represent a novel therapeutic strategy against the synaptic dysfunctions underlying the pathophysiology of phantom pain.Abstract:
The insular cortex (IC) is an important forebrain structure involved in pain perception and taste memory formation. Using a 64-channel multi-electrode array system, we recently identified and characterized two major forms of synaptic plasticity in the adult mouse IC: long-term potentiation (LTP) and long-term depression (LTD). In this study, we investigate injury-related metaplastic changes in insular synaptic plasticity after distal tail amputation. We found that tail amputation in adult mice produced a selective loss of low frequency stimulation-induced LTD in the IC, without affecting (RS)-3,5-dihydroxyphenylglycine (DHPG)-evoked LTD. The impaired insular LTD could be pharmacologically rescued by priming the IC slices with a lower dose of DHPG application, a form of metaplasticity which involves activation of protein kinase C but not protein kinase A or calcium/calmodulin-dependent protein kinase II. These findings provide important insights into the synaptic mechanisms of cortical changes after peripheral amputation and suggest that restoration of insular LTD may represent a novel therapeutic strategy against the synaptic dysfunctions underlying the pathophysiology of phantom pain.read more
Citations
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Journal ArticleDOI
Metabotropic Glutamate Receptor Dependent Cortical Plasticity in Chronic Pain.
Kohei Koga,Shermaine Li,Min Zhuo +2 more
TL;DR: It is proposed that targeting mGluRs in the cortical areas including the ACC and IC may provide a new therapeutic strategy for the treatment of chronic pain, phantom pain or anxiety.
Journal ArticleDOI
No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex
TL;DR: The findings suggest that TRPV1 may not be a viable target for treating chronic pain, especially at the cortical level, in the anterior cingulate cortex of adult mice.
Journal ArticleDOI
Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity.
Yong-Jie Wang,Yong-Jie Wang,Yong-Jie Wang,Ming-Gang Liu,Jing-Hua Wang,Jing-Hua Wang,Wei Cao,Wei Cao,Cheng Wu,Cheng Wu,Zi-Yue Wang,Zi-Yue Wang,Li Liu,Fan Yang,Zhihui Feng,Li Sun,Li Sun,Fuxing Zhang,Yi Shen,Yi Shen,Yu-Dong Zhou,Yu-Dong Zhou,Min Zhuo,Min Zhuo,Jianhong Luo,Jianhong Luo,Tian-Le Xu,Xiang-Yao Li,Xiang-Yao Li +28 more
TL;DR: It is shown that nerve injury suppresses long-term depression and downregulates Casp3 in the anterior cingulate cortex and suggested that restoration of LTD via Casp 3 provides a therapeutic strategy for neuropathic pain management.
Journal ArticleDOI
Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity.
TL;DR: Roles and mechanisms of P2X7 receptors in IC in development of visceral hypersensitivity of adult rats with neonatal maternal deprivation (NMD) are investigated.
Journal ArticleDOI
Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice.
Yinglu Liu,Yinglu Liu,Yinglu Liu,Qi-Yu Chen,Qi-Yu Chen,Qi-Yu Chen,Jung Hyun Lee,Xu-Hui Li,Xu-Hui Li,Xu-Hui Li,Shengyuan Yu,Min Zhuo,Min Zhuo,Min Zhuo +13 more
TL;DR: Direct evidence is provided that CGRP contributes to synaptic potentiation in the IC, and the AC1 inhibitor NB001 may be beneficial for the treatment of migraine in the future.
References
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Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
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TL;DR: A very strong direct relationship is reported between the amount of cortical reorganization and the magnitude of phantom limb pain (but not non-painful phantom phenomena) experienced after arm amputation, indicating that phantom-limb pain is related to, and may be a consequence of, plastic changes in primary somatosensory cortex.
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