Loss of long-term depression in the insular cortex after tail amputation in adult mice
Reads0
Chats0
TLDR
It is found that tail amputation in adult mice produced a selective loss of low frequency stimulation-induced LTD in the IC, without affecting (RS)-3,5-dihydroxyphenylglycine (DHPG)-evoked LTD, and it is suggested that restoration of insular LTD may represent a novel therapeutic strategy against the synaptic dysfunctions underlying the pathophysiology of phantom pain.Abstract:
The insular cortex (IC) is an important forebrain structure involved in pain perception and taste memory formation. Using a 64-channel multi-electrode array system, we recently identified and characterized two major forms of synaptic plasticity in the adult mouse IC: long-term potentiation (LTP) and long-term depression (LTD). In this study, we investigate injury-related metaplastic changes in insular synaptic plasticity after distal tail amputation. We found that tail amputation in adult mice produced a selective loss of low frequency stimulation-induced LTD in the IC, without affecting (RS)-3,5-dihydroxyphenylglycine (DHPG)-evoked LTD. The impaired insular LTD could be pharmacologically rescued by priming the IC slices with a lower dose of DHPG application, a form of metaplasticity which involves activation of protein kinase C but not protein kinase A or calcium/calmodulin-dependent protein kinase II. These findings provide important insights into the synaptic mechanisms of cortical changes after peripheral amputation and suggest that restoration of insular LTD may represent a novel therapeutic strategy against the synaptic dysfunctions underlying the pathophysiology of phantom pain.read more
Citations
More filters
Journal ArticleDOI
GluA1 Phosphorylation Contributes to Postsynaptic Amplification of Neuropathic Pain in the Insular Cortex
Shuang Qiu,Ming Zhang,Yan Liu,Yan-yan Guo,Huan Zhao,Qian Song,Ming-gao Zhao,Richard L. Huganir,Jianhong Luo,Hui Xu,Min Zhuo +10 more
TL;DR: The results suggest that the expression of AMPARs is enhanced in the insular cortex after nerve injury by a pathway involving AC1, AKAP79/150, and PKA, and such enhancement may at least in part contribute to behavioral sensitization together with other cortical regions, such as the anterior cingulate and the prefrontal cortices.
Journal ArticleDOI
Contribution of synaptic plasticity in the insular cortex to chronic pain
TL;DR: LTP of glutamatergic transmission in pain related cortical areas serves as a key mechanism for chronic pain.
Journal ArticleDOI
Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice
TL;DR: There is strong evidence that the selective AC1 inhibitor NB001 can be used to inhibit pain-related cortical L-LTP without affecting basal synaptic transmission and basic mechanisms for possible side effects of gabapentin in the central nervous system and its ineffectiveness in some patients with neuropathic pain are provided.
Journal ArticleDOI
Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms.
M. Liu,Hu Song Li,Wei Guang Li,Yan Jiao Wu,Shi Ning Deng,Chen Huang,Oleksandr Maximyuk,Volodymyr A. Sukach,Oleg Krishtal,Michael X. Zhu,Tian Le Xu +10 more
TL;DR: It is found that genetic deletion or pharmacological blockade of ASIC1a greatly reduced, but did not fully abolish, the probability of long-term potentiation (LTP) induction by either single or repeated high frequency stimulation or theta burst stimulation in the CA1 region.
Journal ArticleDOI
Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs.
Pierpaolo Di Giminiani,Sandra Edwards,Emma M. Malcolm,Matthew C. Leach,Mette S. Herskin,Dale A. Sandercock +5 more
TL;DR: Tail amputation in pigs appears to evoke acute and sustained changes in peripheral mechanical sensitivity, which resemble features of neuropathic pain reported in humans and other species and provides new information on implications for the welfare of animals subjected to this type of injury.
References
More filters
Journal ArticleDOI
Hippocampal Synaptic Metaplasticity Requires Inhibitory Autophosphorylation of Ca2+/Calmodulin-Dependent Kinase II
Lingling Zhang,Timo Kirschstein,Britta Sommersberg,Malte Merkens,Denise Manahan-Vaughan,Ype Elgersma,Heinz Beck +6 more
TL;DR: Modulation of αCaMKII activity via autophosphorylation at Thr305/Thr306 is a key mechanism for metaplasticity that may be of importance in the integration of temporally separated episodes of activity.
Journal ArticleDOI
In vivo long-term potentiation in the insular cortex: NMDA receptor dependence.
TL;DR: The results suggest that in vivo tetanus induced LTP of the Bla-IC projection is a possible mechanism for the memory-related functions performed by the IC.
Journal ArticleDOI
Altered hippocampal long-term potentiation after peripheral nerve injury in mice.
TL;DR: The results suggest that beta-adrenergic functions are changed in chronic pain conditions, which may underlie the deficiency of long-term potentiation.
Journal ArticleDOI
A role for protein kinase C in a form of metaplasticity that regulates the induction of long-term potentiation at CA1 synapses of the adult rat hippocampus
TL;DR: It is suggested that neither PKC nor PKA is required to induce LTP at this synapse, however, PKC is involved in the regulation of LTP induction, via the molecular switch process.
Journal ArticleDOI
‘Silent’ priming of translation-dependent LTP by β-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors
Gustavo Tenorio,Steven A. Connor,Diane Guévremont,Wickliffe C. Abraham,Joanna M. Williams,Thomas J. O'Dell,Peter V. Nguyen +6 more
TL;DR: The results indicate that β-ARs can modulate hippocampal synaptic plasticity by priming synapses for the future induction of late-phase LTP through up-regulation of translational processes, one consequence of which is the trafficking of AMPARs to the cell surface.
Related Papers (5)
Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKMζ in the Anterior Cingulate Cortex
Xiang-Yao Li,Xiang-Yao Li,Hyoung-Gon Ko,Tao Chen,Tao Chen,Giannina Descalzi,Kohei Koga,Hansen Wang,Susan S. Kim,Yuze Shang,Chuljung Kwak,Soowon Park,Jaehoon Shim,Jaehoon Shim,Kyungmin Lee,Kyungmin Lee,Graham L. Collingridge,Graham L. Collingridge,Bong-Kiun Kaang,Bong-Kiun Kaang,Min Zhuo,Min Zhuo +21 more