Loss of long-term depression in the insular cortex after tail amputation in adult mice
Citations
76 citations
Cites background from "Loss of long-term depression in the..."
...Peripheral nerve injury or tail amputation produces long-term upregulation or activation of the synaptic NMDARs (Zhuo, 1998; Qiu et al., 2013) or loss of long-term depression in the insular cortex (Liu and Zhuo, 2014)....
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..., 2013) or loss of long-term depression in the insular cortex (Liu and Zhuo, 2014)....
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41 citations
Cites background from "Loss of long-term depression in the..."
...in sensory and emotion-related cortical areas such as the insular cortex (IC) and anterior cingulate cortex (ACC), both E-LTP and L-LTP have been recently reported in adult mice [11-14]....
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References
62 citations
"Loss of long-term depression in the..." refers background in this paper
...There are only a few reports showing that priming stimulation of group II mGluRs inhibits or facilitates the subsequent induction of LTD in CA1 or dentate gyrus, respectively [76,77], while prior activation of group I mGluRs has no effect [77]....
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61 citations
"Loss of long-term depression in the..." refers background or methods or result in this paper
...Tail amputation Mouse 64-channel field potential recording ACC LFS (1 Hz, 15 min) Rescue of lost LTD by mGluR1 activation [38]...
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...In the present study, we used a 64-channel multi-electrode dish (MED64) recording system [23,38,43] to examine injury-related metaplastic changes in insular LTD caused by tail amputation in the adult mice....
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...Specifically, we found that peripheral amputation abolished LTD and enhanced extracellular signal-regulated kinase activation in the rodent ACC at two weeks [37-39]....
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...This result in the IC is in contrast to that in the ACC, where tail amputation prevented the occurrence of both LFS-induced LTD and mGluR1-mediated LTD [38]....
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...These observations are consistent with our previous results in the ACC [38], suggesting that PKC, but not CaMKII or PKA, acts as a major mediator in mGluR-evoked metaplasticity in the IC in tail-amputated animals....
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58 citations
"Loss of long-term depression in the..." refers background or result in this paper
...By contrast, we did not find any participation of PKA or CaMKII in the process, although there are some previous reports indicating their involvement in the regulation of metaplasticity [66-68]....
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...Besides PKC, CaMKII and PKA have also been shown to mediate certain forms of metaplasticity [66-68]....
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57 citations
"Loss of long-term depression in the..." refers background in this paper
...Genetic [14,15] or pharmacological [16-19] manipulation of the IC could alter the pain sensitivity....
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...There is considerable evidence indicating the critical role of the IC in pain perception and memory storage [2,3,16-18]....
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57 citations