Loss of long-term depression in the insular cortex after tail amputation in adult mice
Citations
76 citations
Cites background from "Loss of long-term depression in the..."
...Peripheral nerve injury or tail amputation produces long-term upregulation or activation of the synaptic NMDARs (Zhuo, 1998; Qiu et al., 2013) or loss of long-term depression in the insular cortex (Liu and Zhuo, 2014)....
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..., 2013) or loss of long-term depression in the insular cortex (Liu and Zhuo, 2014)....
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65 citations
41 citations
Cites background from "Loss of long-term depression in the..."
...in sensory and emotion-related cortical areas such as the insular cortex (IC) and anterior cingulate cortex (ACC), both E-LTP and L-LTP have been recently reported in adult mice [11-14]....
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References
166 citations
"Loss of long-term depression in the..." refers background in this paper
...The involvement of IC in chronic pain has also been confirmed by animal experiments, showing the presence of nociceptive neurons [10,11] and pain-evoked...
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165 citations
"Loss of long-term depression in the..." refers background in this paper
...It has been previously reported that peripheral inflammation or nerve injury could trigger a long-term enhancement of excitatory synaptic transmission in various brain regions, such as ACC [51-54], amygdala [55-57], and hippocampus [58]....
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163 citations
"Loss of long-term depression in the..." refers background in this paper
...Moreover, electrical stimulation of IC directly elicits painful sensations in human subjects [7-9]....
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160 citations
"Loss of long-term depression in the..." refers background or methods in this paper
...Specifically, although either tail or digit amputation triggered a complete loss of LTD in the ACC [37,38] or the IC (the present study), almost the same manipulation has no effect on LTD induction in the hippocampus or parietal cortex [37,45]....
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...Specifically, we found that peripheral amputation abolished LTD and enhanced extracellular signal-regulated kinase activation in the rodent ACC at two weeks [37-39]....
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...Digit amputation Rat Field potential recording ACC and parietal cortex LFS (1 Hz, 15 min) Lost LTD in the ACC but not parietal cortex [37]...
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...We previously demonstrated that digit amputation in rats or tail amputation in mice triggered long-lasting plastic alterations in the anterior cingulate cortex (ACC), including an enhancement of excitatory synaptic responses in vivo [35,36], loss of long-term depression (LTD) in vitro [37,38] and activation of activity-dependent immediate early genes [37,39]....
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...In the present study, we performed electrophysiological recordings at 2 weeks after tail amputation (Figure 1A), on the basis of our previous reports showing an evident plastic change in the ACC at this time point [37-39]....
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159 citations
"Loss of long-term depression in the..." refers background in this paper
...In particular, human brain imaging studies have demonstrated the activation of IC in a broad range of pain conditions [4-6]....
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