Loss of mandibular lymph node integrity is associated with an increase in sensitivity to HSV-1 infection in CD118-deficient mice.
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...In contrast, an increase in macrophages within the CNS of IFNAR-A1 deficient mice has been observed [138]....
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...However, analysis of brain cortex and ependyma for cytokine and chemokine (TNF-a and CXCL10) expression by suspension array or leukocyte infiltrate (including neutrophils, macrophages, inflammatory monocytes, and NK cells) by flow cytometry revealed no significant difference in levels or cell numbers comparing peptide- to vehicle-treated mice day 7 to 8 p.i. (data not shown)....
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...We speculate CXCL10 may serve as an easily accessible predictor of inflammation severity in patients with no previous history of neuroinflammatory disease....
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...Likewise, HSE WT mice had detectable levels of IL-1a, CCL2, CXCL1, CXCL9, and CXCL10, with CXCL1 and CXCL10 expression significantly above that recovered in the CSF of non-HSE WT mice day 8 p.i. (Fig....
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...Associated with encephalitis is an increase in CXCL1 and CXCL10 levels in the cerebral spinal fluid, TNF-a expression in the ependymal region, and the influx of neutrophils of encephalitic mouse brains....
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...for CD118 mice) or the relationship between a functional type I IFN pathway and HSV-1–induced CXCL10 (34)....
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References
1,069 citations
"Loss of mandibular lymph node integ..." refers background in this paper
...I FN- (type I IFNs) are cytokines produced by numerous cell types typically associated with antiviral or antiproliferative characteristics and more recently, appreciated for their potential application in controlling autoimmune processes including multiple sclerosis (1, 2)....
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992 citations
"Loss of mandibular lymph node integ..." refers background in this paper
...Different DC subtypes are known to promote Th1 or Th2 responses (55) in which type I IFNs can contribute toward Th1 (16) or Th2 (56) development....
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915 citations
"Loss of mandibular lymph node integ..." refers background in this paper
...In mice infected with lymphocytic choriomeningitis virus, the loss of type I IFN signaling greatly diminishes clonal expansion of CD8 T cells as a result of a defect in cell survival (64)....
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"Loss of mandibular lymph node integ..." refers background in this paper
...Type I IFNs facilitate the development of T cell immunity including TAP expression (62), which would greatly benefit the host and CD8 T cell responses through cross-priming (63)....
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