Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex
Citations
263 citations
Cites background from "Loss of microRNAs in pyramidal neur..."
...This research directly implicates miRNAs as functioning in inhibitory synapses and illustrates the global effects cellspecific knockdown of miRNAs can impart (Hsu et al., 2012)....
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220 citations
Cites background from "Loss of microRNAs in pyramidal neur..."
...It is important that nuclear miRNA processing is critical for proper synaptic function as shown by Ullian and colleagues that deletion of DGCR8 leads to defects of inhibitory synaptic transmission (Hsu et al., 2012)....
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165 citations
Cites background from "Loss of microRNAs in pyramidal neur..."
...In this context, it is interesting that down-regulating miRNAs selectively in excitatory neurons, in mouse forebrain, produces discrete deficits in shortterm plasticity and inhibitory neurotransmission that are reminiscent in some ways of a schizophrenia phenotype [30,31]....
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106 citations
Cites background from "Loss of microRNAs in pyramidal neur..."
...Although the gross anatomical features are retained, reduction in dendritic complexity, alteration in spine size and density [72] as well as selective decrease in inhibitory network [73] and deficient adult neurogenesis [74] has been reported in relation to monoallelic DGCR8 knockdown....
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89 citations
Cites background from "Loss of microRNAs in pyramidal neur..."
...In addition, Dgcr8 knockout mice have deficits in the development of excitatory synapses and a reduction of parvalbumin interneurons in the prefrontal cortex [2,48]....
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References
32,946 citations
"Loss of microRNAs in pyramidal neur..." refers background in this paper
...MicroRNAs (miRNAs) constitute a class of highly-conserved, ~22- 24 nucleotide (nt) long non-coding RNAs that bind to the 3’ untranslated region of target mRNA species, leading to translational repression or mRNA degradation (reviewed in Bartel, 2004)....
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...For instance, endo-siRNAs processed by Dicer typically result in target degradation, whereas Dgcr8derived miRNAs more commonly act via translational repression (Ambros, 2004; Bartel, 2004)....
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30,462 citations
"Loss of microRNAs in pyramidal neur..." refers methods in this paper
...All qPCR reactions were performed in triplicate and relative quantifications were calculated using the Pfaffl method (Pfaffl, 2001)....
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9,986 citations
6,638 citations
"Loss of microRNAs in pyramidal neur..." refers methods in this paper
...Mice were observed for at least 30 minutes after pilocarpine injection, and seizures were quantified by using the classification of Racine (1972)....
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2,854 citations