Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex
Ruby Hsu,Claude M. Schofield,Cassandra G. Dela Cruz,Dorothy M. Jones-Davis,Robert Blelloch,Erik M. Ullian +5 more
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TLDR
A vital role for miRNAs in governing essential aspects of inhibitory transmission and interneuron development in the mammalian nervous system is suggested.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2012-07-01 and is currently open access. It has received 51 citations till now. The article focuses on the topics: Interneuron & Prefrontal cortex.read more
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Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure
Prakash K. Rao,Yumiko Toyama,H. Rosaria Chiang,Sumeet Gupta,Michael Bauer,Rostislav Medvid,Ferenc Reinhardt,Ronglih Liao,Monty Krieger,Rudolf Jaenisch,Harvey F. Lodish,Robert Blelloch +11 more
TL;DR: A critical role for microRNAs in maintaining cardiac function in mature cardiomyocytes is revealed and the possibility that only a handful of micro RNAs may ultimately be responsible for the dramatic cardiac phenotype seen in the absence of dgcr8 is raised.
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Expression, covariation, and genetic regulation of miRNA Biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease.
TL;DR: This study provides a global survey of the expression and regulation of key miRNA biogenesis genes in brain and provides preliminary support for the involvement of these genes and their product miRNAs in addiction and psychiatric disease processes.
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Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo
Wen-Ting Guo,Yangming Wang +1 more
TL;DR: In future, Dgcr8 knockout approaches coupled with innovations in miRNA rescue strategy may provide further insights into miRNA functions in vitro and in vitro, and current progresses on understanding miRNA-independent functions of miRNA biogenesis factors.
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A Synaptic Function Approach to Investigating Complex Psychiatric Diseases
TL;DR: The advantages of using a synaptic function approach to studying mouse models of 22q11DS are discussed, recent findings are reviewed, and they in the broader context of 22Q11DS and schizophrenia are discussed.
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Transsynaptic modality codes in the brain: possible involvement of synchronized spike timing, microRNAs, exosomes and epigenetic processes
John Smythies,Lawrence Edelstein +1 more
TL;DR: The possibility that the afferent neuron at the neuromuscular junction carries a cargo of Wg and Evi, which are large molecular transsynaptic signaling agents (LMTSAs), which represents a mechanism for information transfer involving the postsynaptic neuron as a whole is explored.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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A new mathematical model for relative quantification in real-time RT-PCR.
TL;DR: This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript and presents a new mathematical model that needs no calibration curve.
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The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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Modification of seizure activity by electrical stimulation. II. Motor seizure.
TL;DR: It was found that the development of motor seizures by stimulation of the amygdala resulted in an increased ability of the contralateral amygdala, and the septal area, but not of the hippocampus, to drive motor seizures when stimulated (“transfer”).
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Interneurons of the neocortical inhibitory system.
TL;DR: This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.