Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex
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Cites background from "Loss of microRNAs in pyramidal neur..."
...Deletion of DGCR8, which affects the production of the precursor microRNA, results in a reduction in brain size and loss of inhibitory synaptic neurotransmission (Babiarz et al., 2011; Hsu et al., 2012)....
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Cites background from "Loss of microRNAs in pyramidal neur..."
...Knockout of DGCR8 in pyramidal neurons also resulted in severe microcephaly, cell loss, altered inhibitory synaptic transmission, and premature death (Hsu et al. 2012)....
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References
32,946 citations
"Loss of microRNAs in pyramidal neur..." refers background in this paper
...MicroRNAs (miRNAs) constitute a class of highly-conserved, ~22- 24 nucleotide (nt) long non-coding RNAs that bind to the 3’ untranslated region of target mRNA species, leading to translational repression or mRNA degradation (reviewed in Bartel, 2004)....
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...For instance, endo-siRNAs processed by Dicer typically result in target degradation, whereas Dgcr8derived miRNAs more commonly act via translational repression (Ambros, 2004; Bartel, 2004)....
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30,462 citations
"Loss of microRNAs in pyramidal neur..." refers methods in this paper
...All qPCR reactions were performed in triplicate and relative quantifications were calculated using the Pfaffl method (Pfaffl, 2001)....
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9,986 citations
6,638 citations
"Loss of microRNAs in pyramidal neur..." refers methods in this paper
...Mice were observed for at least 30 minutes after pilocarpine injection, and seizures were quantified by using the classification of Racine (1972)....
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2,854 citations