Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex
Ruby Hsu,Claude M. Schofield,Cassandra G. Dela Cruz,Dorothy M. Jones-Davis,Robert Blelloch,Erik M. Ullian +5 more
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TLDR
A vital role for miRNAs in governing essential aspects of inhibitory transmission and interneuron development in the mammalian nervous system is suggested.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2012-07-01 and is currently open access. It has received 51 citations till now. The article focuses on the topics: Interneuron & Prefrontal cortex.read more
Citations
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Journal ArticleDOI
MicroRNAs as regulators of drug abuse and immunity.
TL;DR: It is hypothesized that chronic drug abuse leads to aberrant expression of several miRNAs, and then aberrant mi RNAs influence the innate and adaptive immunity, especially differentiation and function of T cells and B cells, through down-regulated miRNas’ target gene expression.
Journal ArticleDOI
EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia.
Andrea L. Johnstone,Jiaqi J. O'Reilly,Annika J Patel,Zhihong Guo,Nadja S. Andrade,Marco Magistri,Lubov Nathanson,Rustam Esanov,Brooke H. Miller,Gustavo Turecki,Zane Zeier,Claes Wahlestedt +11 more
TL;DR: EZH1 is dysregulated in schizophrenia, sensitive to antipsychotic medications, and a brain-enriched miR-132 target that controls neurobehavioral phenotypes.
Journal ArticleDOI
Can we protect the brain via preconditioning? Role of microRNAs in neuroprotection.
TL;DR: The use of several preconditioning treatment paradigms in the clinic to protect patients against an ischemic insult in heart pathologies shows the importance of understanding the underlying mechanism to preconditionsing, and its translation in the Clinic in brain disorders.
Book ChapterDOI
Chapter 13 – Small RNA Dysregulation in Neurocognitive and Neuropsychiatric Disorders
TL;DR: The evidence for miRNA dysregulation and dysfunction with schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders, and other neurocognitive syndromes is discussed as well as their potential as biomarkers or the rapeutics for these disorders.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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A new mathematical model for relative quantification in real-time RT-PCR.
TL;DR: This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript and presents a new mathematical model that needs no calibration curve.
Journal ArticleDOI
The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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Modification of seizure activity by electrical stimulation. II. Motor seizure.
TL;DR: It was found that the development of motor seizures by stimulation of the amygdala resulted in an increased ability of the contralateral amygdala, and the septal area, but not of the hippocampus, to drive motor seizures when stimulated (“transfer”).
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Interneurons of the neocortical inhibitory system.
TL;DR: This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.