Loss of Nfkb1 leads to early onset aging
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"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...Primary cells have a limited lifespan in culture and undergo senescence following serial passage [5]....
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...Regardless of mechanism, cellular senescence is a central finding associated with mammalian aging [5], an observation emphasized by a report demonstrating that apoptotic removal of senescent cells preserves tissue homeostasis and extends overall animal health [6, 7]....
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2,738 citations
"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...Regardless of mechanism, cellular senescence is a central finding associated with mammalian aging [5], an observation emphasized by a report demonstrating that apoptotic removal of senescent cells preserves tissue homeostasis and extends overall animal health [6, 7]....
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...Moreover, a recent study demonstrated that apoptotic removal of senescent cells delays the appearance of certain age-related findings [6]....
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2,549 citations
2,114 citations
"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...While a direct link between cellular senescence and organismal aging has not been definitively established, aged tissues have higher levels of senescent cells than young [43]....
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1,838 citations
"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...the cyclin-dependent kinase inhibitors, p21 and p16 (CDKN1a and CDKN2a, respectively), factors that are closely associated with senescence [21]....
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