Loss of Nfkb1 leads to early onset aging
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"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...Regardless of mechanism, cellular senescence is a central finding associated with mammalian aging [5], an observation emphasized by a report demonstrating that apoptotic removal of senescent cells preserves tissue homeostasis and extends overall animal health [6, 7]....
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272 citations
"Loss of Nfkb1 leads to early onset ..." refers result in this paper
...Although we have endeavored to minimize this by using single strain littermate mice, C57BL/6 mice have been reported to have early onset of certain neurodegenerative findings including hearing loss [40] that may contribute to some of the observations noted in our study....
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233 citations
"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...Although age-associated increase in overall NF-κB binding has been described [28-30, 46-49], a change in dimer composition has not previously been reported....
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...As previously reported with other tissue [28-30], a general increase in NF-κB DNA binding is evident in brains of old mice compared to young (Supplemental Fig....
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232 citations
"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...While accumulation of DNA damage has long been considered the central cause of aging [1], more recent observations suggest that aging is the result of a continuation of early-life hyperfunction programs [2-4]....
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