Loss of Nfkb1 leads to early onset aging
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"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...While p50 protein level remains stable with advancing age, p52 increases, a finding also noted in rat liver and gastric mucosa [47, 50]....
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94 citations
62 citations
"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...While the mechanistic link between GFAP staining and aging remains unclear, a strong correlation between these findings is evident both in rodents and humans [20, 38, 39]....
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...However, given the association between aging and CNS white matter glial fibrillary acidic protein (GFAP) staining [20], we examined GFAP reactivity in these animals....
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56 citations
"Loss of Nfkb1 leads to early onset ..." refers background in this paper
...Although age-associated increase in overall NF-κB binding has been described [28-30, 46-49], a change in dimer composition has not previously been reported....
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...As previously reported with other tissue [28-30], a general increase in NF-κB DNA binding is evident in brains of old mice compared to young (Supplemental Fig....
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50 citations
"Loss of Nfkb1 leads to early onset ..." refers result in this paper
...Nevertheless, other organs have also been implicated in the premature aging of Nfkb1 mice as exemplified both by our results and the early emphysema and decreased skin thickness noted by others [41, 42]....
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