Lovastatin Nanoparticle Synthesis and Characterization for Better Drug Delivery
Citations
116 citations
Cites background from "Lovastatin Nanoparticle Synthesis a..."
...Approximately 40% of drugs in the pipeline and 70% of synthetic therapeutic molecules are plagued with poor solubility, oral bioavailability, and delivery.(8,9) Drugs with poor solubility suffer from limited transport after oral administration because of a low concentration gradient between the gut and blood vessels....
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27 citations
26 citations
Cites background from "Lovastatin Nanoparticle Synthesis a..."
...The nano-aided drug delivery system is a suitable choice for poorly soluble lipophilic drugs (Seenivasan et al., 2011)....
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18 citations
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References
1,302 citations
"Lovastatin Nanoparticle Synthesis a..." refers background in this paper
...This paper discusses emerging formulation designs for the delivery of poorly water-soluble lovastatin, their characterization, and applications....
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...Carrier development for the parenteral administration of these drugs has many problems including the massive use of surface-active excipients for solubilization [1]....
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...These systems demand suitable conditions for drug delivery, viz., the use of physiologically tolerated lipids, large-scale production, protection of drugs from degradation, improved bioavailability, minimum level of toxicity, and controlledrelease characteristics....
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1,186 citations
Additional excerpts
...Keywords: Lovastatin, nanoparticles, solid lipid nanoparticles, lipid emulsions, nano-structured lipid carriers....
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768 citations
"Lovastatin Nanoparticle Synthesis a..." refers background in this paper
...Lovastatin, a cholesterol-lowering agent, is isolated from strains such as Aspergillus, Monascus, and Streptomycetes species....
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...The potential problems associated with conventional oraladministrated system (tablets) are non-specific targeting, side effects due to high dosage, and poor stability....
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...Keywords: Lovastatin, nanoparticles, solid lipid nanoparticles, lipid emulsions, nano-structured lipid carriers....
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603 citations
"Lovastatin Nanoparticle Synthesis a..." refers background in this paper
...This paper discusses emerging formulation designs for the delivery of poorly water-soluble lovastatin, their characterization, and applications....
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...Keywords: Lovastatin, nanoparticles, solid lipid nanoparticles, lipid emulsions, nano-structured lipid carriers....
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...Hence, this compound is encapsulated or coated with a suitable carrier to enhance its bioavailability and other properties, viz., dissolution rate, half-life period, drug loading capacity, and maximum attainable plasma concentration....
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...Another important parameter is lipophilicity which determines the nature of the diffusion system....
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...However, the oral administration of this drug has certain limitations, viz., poor bioavailability, nonhepatic shunting, side effects due to higher dosage, more excretion in bile....
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523 citations
Additional excerpts
...Keywords: Lovastatin, nanoparticles, solid lipid nanoparticles, lipid emulsions, nano-structured lipid carriers....
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