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Journal Article•DOI•

Lovastatin Nanoparticle Synthesis and Characterization for Better Drug Delivery

A. Seenivasan, Tapobrata Panda1, Thomas Theodore•
Indian Institute of Technology Madras1
03 Aug 2011-The Open Biotechnology Journal-Vol. 5, Iss: 1, pp 28-32
TL;DR: Nano drug delivery system is the latest technology employed in various medicinal applications and NLCs are a smarter generation of drug delivery carriers for lovastatin, a important drug which arrests the rate-limiting step of the cholesterol cascade.
Abstract: Nano drug delivery system is the latest technology employed in various medicinal applications. This technol- ogy can be adapted to the conventional drug administration due to its site-specific targeting phenomena. The oral lipo- philic drug administration has its drawbacks due to poor solubility and bioavailability. Lipid-based carrier systems are now widely popular due to improved efficiency, especially for lovastatin delivery. Lovastatin is an important drug which arrests the rate-limiting step of the cholesterol cascade. This drug has short half-lives, poor oral-administered bioavailabil- ity, poor solubility, and is rapidly metabolizable. Based on the composition, the drug delivery carriers are classified into solid lipid nanoparticles (SLNs), lipid emulsions (LEs), and nanostructured lipid carriers (NLCs). Among them, NLCs are a smarter generation of drug delivery carriers for lovastatin. The selection of various lipid systems and their formulation are discussed in this paper. Moreover, the characterization of these carrier systems to achieve the optimal characteristic features is discussed in a concise manner.

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Citations
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Dissertation•
Formulation and Evaluation of Chitosan Nanoparticles.

[...]

R Balaji
01 Apr 2014
TL;DR: The solid lipid nanoparticles of lovastatin formulation can be effective in treatment of lowering cholesterol and the drug was released from the formulation in a constant manner for the desired period of time.
Abstract: Nanoparticulate drug delivery systems (DDS) have attracted a lot of attention because of their size-dependent properties. Among the array of nanoparticles being currently investigated by pharmaceutical scientists, lipid nanoparticles have taken the lead because of obvious advantages of higher degree of biocompatibility and versatility. These systems are commercially viable to formulate pharmaceuticals for topical, oral, pulmonary or parenteral delivery. The co-administration of lipids with drugs can also impact their absorption pathway although most orally administered compounds gain access to the systemic circulation via the portal vein, some highly lipophilic drugs are transported directly to the systemic circulation via intestinal lymphatic’s, which improves oral bioavailability of poorly water soluble API like lovastatin. The solid lipid nanoparticles of lovastatin formulation can be effective in treatment of lowering cholesterol and the drug was released from the formulation in a constant manner for the desired period of time. The solid lipid nanoparticles of lovastatin evaluated here has potential in reduction of cholesterol, for the reason that improved solubility can improve the bioavailability of the poorly soluble drug lovastatin and considered to be promising for prolonging the release of drug compared with other conventional formulations.
References
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Journal Article•DOI•
Solid lipid nanoparticles for parenteral drug delivery.

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S. A. Wissing, Oliver Kayser, Rainer H. Müller1•
Free University of Berlin1
07 May 2004-Advanced Drug Delivery Reviews
TL;DR: The biological activity of parenterally applied SLN and biopharmaceutical aspects such as pharmacokinetic profiles as well as toxicity aspects are reviewed.

1,302 citations

"Lovastatin Nanoparticle Synthesis a..." refers background in this paper

  • ...This paper discusses emerging formulation designs for the delivery of poorly water-soluble lovastatin, their characterization, and applications....

    [...]

  • ...Carrier development for the parenteral administration of these drugs has many problems including the massive use of surface-active excipients for solubilization [1]....

    [...]

  • ...These systems demand suitable conditions for drug delivery, viz., the use of physiologically tolerated lipids, large-scale production, protection of drugs from degradation, improved bioavailability, minimum level of toxicity, and controlledrelease characteristics....

    [...]

Journal Article•DOI•
Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.

[...]

Jana Pardeike1, Aiman Hommoss1, Rainer H. Müller1•
Free University of Berlin1
21 Jan 2009-International Journal of Pharmaceutics
TL;DR: An overview of the cosmetic products currently on the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown and the lipid nanoparticles are a "nanosafe" carrier.

1,186 citations

Additional excerpts

  • ...Keywords: Lovastatin, nanoparticles, solid lipid nanoparticles, lipid emulsions, nano-structured lipid carriers....

    [...]

Journal Article•DOI•
Lipid-based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic

[...]

Anu Puri1, Kristin H. Loomis2, Brandon Smith1, Jae-Ho Lee1, Amichai Yavlovich1, Eliahu Heldman3, Robert Blumenthal1 •
National Institutes of Health1, Emory University2, Ben-Gurion University of the Negev3
01 Jan 2009-Critical Reviews in Therapeutic Drug Carrier Systems
TL;DR: This review will primarily focus on the recent advances and updates on lipid-based nanoparticles for their projected applications in drug delivery, including a review of current activities in the field of liposomes, and challenging issues of targeting and triggering will be discussed in detail.
Abstract: In recent years, various nanotechnology platforms in the area of medical biology, including both diagnostics and therapy, have gained remarkable attention. Moreover, research and development of engineered multifunctional nanoparticles as pharmaceutical drug carriers have spurred exponential growth in applications to medicine in the last decade. Design principles of these nanoparticles, including nano-emulsions, dendrimers, nano-gold, liposomes, drug-carrier conjugates, antibody-drug complexes, and magnetic nanoparticles, are primarily based on unique assemblies of synthetic, natural, or biological components, including but not limited to synthetic polymers, metal ions, oils, and lipids as their building blocks. However, the potential success of these particles in the clinic relies on consideration of important parameters such as nanoparticle fabrication strategies, their physical properties, drug loading efficiencies, drug release potential, and, most importantly, minimum toxicity of the carrier itself. Among these, lipid-based nanoparticles bear the advantage of being the least toxic for in vivo applications, and significant progress has been made in the area of DNA/RNA and drug delivery using lipid-based nanoassemblies. In this review, we will primarily focus on the recent advances and updates on lipid-based nanoparticles for their projected applications in drug delivery. We begin with a review of current activities in the field of liposomes (the so-called honorary nanoparticles), and challenging issues of targeting and triggering will be discussed in detail. We will further describe nanoparticles derived from a novel class of amphipathic lipids called bolaamphiphiles with unique lipid assembly features that have been recently examined as drug/DNA delivery vehicles. Finally, an overview of an emerging novel class of particles (based on lipid components other than phospholipids), solid lipid nanoparticles and nanostructured lipid carriers will be presented. We conclude with a few examples of clinically successful formulations of currently available lipid-based nanoparticles.

768 citations

"Lovastatin Nanoparticle Synthesis a..." refers background in this paper

  • ...Lovastatin, a cholesterol-lowering agent, is isolated from strains such as Aspergillus, Monascus, and Streptomycetes species....

    [...]

  • ...The potential problems associated with conventional oraladministrated system (tablets) are non-specific targeting, side effects due to high dosage, and poor stability....

    [...]

  • ...Keywords: Lovastatin, nanoparticles, solid lipid nanoparticles, lipid emulsions, nano-structured lipid carriers....

    [...]

Journal Article•DOI•
Nanostructured lipid carriers (NLC) in cosmetic dermal products

[...]

Rainer H. Müller1, R.-D Petersen1, A. Hommoss1, Jana Pardeike1•
Free University of Berlin1
10 Jul 2007-Advanced Drug Delivery Reviews
TL;DR: The article gives an overview of the cosmetic benefits of lipid nanoparticles, that means enhancement of chemical stability of actives, film formation, controlled occlusion, skin hydration, enhanced skin bioavailability and physical stability of the lipid nanoparticle as topical formulations.

603 citations

"Lovastatin Nanoparticle Synthesis a..." refers background in this paper

  • ...This paper discusses emerging formulation designs for the delivery of poorly water-soluble lovastatin, their characterization, and applications....

    [...]

  • ...Keywords: Lovastatin, nanoparticles, solid lipid nanoparticles, lipid emulsions, nano-structured lipid carriers....

    [...]

  • ...Hence, this compound is encapsulated or coated with a suitable carrier to enhance its bioavailability and other properties, viz., dissolution rate, half-life period, drug loading capacity, and maximum attainable plasma concentration....

    [...]

  • ...Another important parameter is lipophilicity which determines the nature of the diffusion system....

    [...]

  • ...However, the oral administration of this drug has certain limitations, viz., poor bioavailability, nonhepatic shunting, side effects due to higher dosage, more excretion in bile....

    [...]

Journal Article•DOI•
Potential of solid lipid nanoparticles in brain targeting.

[...]

Indu Pal Kaur1, Rohit Bhandari, Swati Bhandari, Vandita Kakkar1•
Panjab University, Chandigarh1
21 Apr 2008-Journal of Controlled Release
TL;DR: The barriers to CNS drug delivery, strategies to bypass the blood-brain barrier and characterization methods of SLNs and their usefulness are discussed.

523 citations

Additional excerpts

  • ...Keywords: Lovastatin, nanoparticles, solid lipid nanoparticles, lipid emulsions, nano-structured lipid carriers....

    [...]

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