Low-LET Proton Irradiation of A549 Non-small Cell Lung Adenocarcinoma Cells: Dose Response and RBE Determination
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...The single-fraction C-ion data point with the highest BED is described in Tsujii and Kamada,46 while the highest TCP has been achieved at Tsukuba University, Ibaraki, Japan, in a trial on 58 (T1/T2, 30/28) patients treated with 66Gy(RBE)/10 fractions for peripherally located and 72.6Gy(RBE)/22 fractions for centrally located tumours.42 BED for CPT was calculated using the formula above with d in Gy(RBE) as reported in the publications and the same a/b ratio as for X-rays....
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...Slow protons aremore effective than X-rays in the inactivation of human tumour cell lines.47 A recent experiment in a human NSCLC cell line reported an RBE5 1.9 for 3.9MeV protons compared with X-rays.48 The Tsukuba proton beam line used for the NSCLC treatment42 has been used for in vitro experiments in different human cell lines.49 Apoptosis induction was greater than two-fold the level induced by 10MeV X-ray.49 Other experiments have shown that the signalling cascade following exposure to protons can substantially differ from the damage response to photons.50 A potential advantage of CPT in hypofractionation is the reduced oxygen enhancement ratio (OER) using high-LET radiation....
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...There could be a dose threshold, and it seems to be charge- and energy-dependent, and defining an RBE is even more difficult, considering that most of these end points are not observed at all with X-rays.131 These observations have therefore triggered a number of cellular and molecular studies on neural cells and tissue, to gain understanding of the mechanisms of heavy ion-induced damage in the brain....
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...9MeV protons compared with X-rays.(48) The Tsukuba proton beam line used for the NSCLC treatment(42) has been used for in vitro experiments in different human cell lines....
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"Low-LET Proton Irradiation of A549 ..." refers background in this paper
...(1), LET and flux must be controlled over the entire irradiation field and throughout the irradiation of the cells....
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1,244 citations
"Low-LET Proton Irradiation of A549 ..." refers background in this paper
...Wilson in 1946, recognizing that the unique physical properties of protons might have distinct advantages over photon radiation (4)....
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