LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
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...This cytoskeletal remodelling, often termed structural plasticity, is also induced by stimuli that can lead to LT...
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Cites background from "LTP promotes formation of multiple ..."
...Bifurcating spines (Trommald et al 1990) and ultimately even closely associated pairs of spines emanating from one dendrite and touching the same presynaptic element occur (Toni et al 1999)....
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...Toni et al (1999) then scrutinized these spines for morphological changes and found that in many cases after stimulation there were pairs or triplets of (calcium precipitate– marked) spines making contact with the same presynaptic terminal....
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...This study (Toni et al 1999) was an extension of earlier work from the same laboratory (Buchs & Muller 1996) using a technique to select for the stimulated synapses and therefore the location in which morphological changes were expected to occur....
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...It also is worthwhile to emphasize that although the correlation between LTP and some morphological events such as spinogenesis is well documented (Engert & Bonhoeffer 1999, Toni et al 1999), it is important to take it as such: correlation not necessarily proving causality....
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...Synapses that were already large break apart, forming perforated synapses (Peters & Kaiserman-Abramof 1969, Toni et al 1999)....
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...has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memor...
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"LTP promotes formation of multiple ..." refers methods in this paper
...Methods Culture preparation and stimulation Experiments were performed on hippocampal organotypic cultures prepared as describe...
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"LTP promotes formation of multiple ..." refers methods in this paper
...For the stereological part of the study, the dissector procedure was carried out as describe...
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