Open AccessJournal Article
Lymphosarcoma: virus-induced thymic-independent disease in mice.
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TLDR
A new murine oncogenic virus has been isolated which induces solid lymphoid tumors within a short latent period, and thymic-independent tumor induction distinguishes this virus from the other experimental murine lymphoid leukemia viruses.Abstract:
Summary A new murine oncogenic virus has been isolated which induces solid lymphoid tumors within a short latent period. A unique feature of this disease is the lack of thymic involvement. Thymic-independent tumor induction distinguishes this virus from the other experimental murine lymphoid leukemia viruses. In addition, massive meningeal tumors, a myelocytic leukemoid reaction, and no evidence of a disseminated leukemia constitute this disease syndrome.read more
Citations
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The c- myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Jerry M. Adams,A W Harris,Carl A. Pinkert,Lynn M. Corcoran,Warren S. Alexander,Suzanne Cory,Richard D. Palmiter,Ralph L. Brinster +7 more
TL;DR: Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin μ or κ enhancer frequently develop a fatal lymphoma within a few months of birth and constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation.
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The molecular biology of chronic myeloid leukemia
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Inhibition of the Abl Protein-Tyrosine Kinase in Vitro and in Vivo by a 2-Phenylaminopyrimidine Derivative
Elisabeth Buchdunger,Jürg Zimmermann,Helmut Mett,Thomas Meyer,Marcel Muller,Brian J. Druker,Nicholas B. Lydon +6 more
TL;DR: An inhibitor (CGP 57148) of the Abl and platelet-derived growth factor (PDGF) receptor protein-tyrosine kinases from the 2-phenylaminopyrimidine class is described, which is highly active in vitro and in vivo and may have therapeutic potential for the treatment of diseases that involve abnormal cellular proliferation induced by Abl protein-tiesine kinase deregulation or PDGF receptor activation.
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Functional macrophage cell lines transformed by Abelson leukemia virus.
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The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias
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References
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Normal and pathologic anatomy of the reticular tissue in laboratory mice, with a classification and discussion of neoplasms.
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Biological studies on a lymphoid-leukemia virus extracted from sarcoma 37. I-origin and introductory investigations.
Journal Article
Influence of prednisolone on Moloney leukemogenic virus in BALB-c mice
TL;DR: Long-term administration of prednisolone to BALB/c mice alters the reactivity of their lymphoid tissue to the oncogenic effects of Moloney leukemia virus, resulting in solid lymphosarcoma or granulocytic leukemia.