Lysosomal enzyme activity in rats with adjuvant-induced arthritis.
TL;DR: It is concluded that the extensive tissue breakdown in adjuvant arthritis is due to the release and degradative action of lysosomal enzymes on connective tissue components.
About: This article is published in Annals of the Rheumatic Diseases.The article was published on 1970-05-01 and is currently open access. It has received 80 citations till now. The article focuses on the topics: Arthritis & Enzyme assay.
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TL;DR: It is suggested thatospholipases are freed from the lysosomes of leucocytes overactive in the endocytosis of carrageenin, and that these attack cell membrane phospholipid to give arachidonic acid which is converted to prostaglandin by freely available tissue enzymes.
124 citations
TL;DR: It is concluded that the extract contains as yet unidentified anti-inflammatory principle(s) and contains alkaloids, saponins, steroids and flavonoids.
Abstract: 1. The anti-inflammatory effect of an alcoholic extract from the flower of Vernonia cinerea (Asteraceae; Less) was tested in adjuvant arthritic rats. 2. Changes in paw volume, body and tissue weights and serum and tissue enzyme activities of ALT, AST, ACP and cathepsin-D in adjuvant rats were reversed by oral administration of 100 mg/kg body weight (BW) of the flower extract. 3. The extract also reversed the major histopathological changes in the hindpaws of the arthritic rats. 4. Phytochemical studies revealed the presence of alkaloids, saponins, steroids and flavonoids. 5. It is concluded that the extract contains as yet unidentified anti-inflammatory principle(s).
113 citations
TL;DR: The object of this is to highlight recent studies that provide a basis for specifically improving procedures employed in screening the activity and mode of action of anti-inflammatory/antiarthritic drugs-especially those with possible disease modifying activity.
Abstract: The pathological and biochemical features of the polyarthritis in rats induced by Freund's adjuvant are briefly reviewed. The object of this is to highlight recent studies that provide a basis for specifically improving procedures employed in screening the activity and mode of action of anti-inflammatory/antiarthritic drugs-especially those with possible disease modifying activity.
101 citations
Journal Article•
99 citations
01 Jan 1979
TL;DR: This review is mainly concerned with the mechanism of action of those non-steroid anti-inflammatory drugs used to ameliorate the signs and symptoms of human acute and chronic inflammation which have the common property of inhibiting fatty acid oxidative cyclization, in particular the formation of prostaglandins and throm-boxanes.
Abstract: This review is mainly concerned with the mechanism of action of those non-steroid anti-inflammatory drugs used to ameliorate the signs and symptoms of human acute and chronic inflammation which have the common property of inhibiting fatty acid oxidative cyclization, in particular the formation of prostaglandins (PGs) and throm-boxanes. We have retained for this group of substances the term PG synthetase inhibitors because thromboxane synthetase can be selectively inhibited by substances which do not affect PG synthesis and do not show anti-inflammatory activity (Moncada et al., 1976). Other types of non-steroid anti-inflammatory agents are reviewed in subsequent chapters.
94 citations
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2,792 citations
Book•
01 Jan 1969
TL;DR: By reading this book as soon as possible, you can renew the situation to get the inspirations and will lead you to always think more and more.
Abstract: Want to get experience? Want to get any ideas to create new things in your life? Read lysosomes in biology and pathology now! By reading this book as soon as possible, you can renew the situation to get the inspirations. Yeah, this way will lead you to always think more and more. In this case, this book will be always right for you. When you can observe more about the book, you will know why you need this.
1,476 citations
TL;DR: A reproducible generalized or focal arthritis, synovitis, periostitis and tendonitis has been induced in rats by intracutaneous injections of a Freund-type adjuvant which was most potent when macerated striated muscle tissue was added to the inoculum.
Abstract: Summary and ConclusionsA reproducible generalized or focal arthritis, synovitis, periostitis and tendonitis has been induced in rats by intracutaneous injections of a Freund-type adjuvant which was...
822 citations
518 citations