Macrophage plasticity and polarization in tissue repair and remodelling.
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TLDR
Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M1 or an M2‐like activation mode.Abstract:
Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2-like activation mode. Macrophages are credited with an essential role in remodelling during ontogenesis. In extraembryonic life, under homeostatic conditions, the macrophage trophic and remodelling functions are recapitulated in tissues such as bone, mammary gland, decidua and placenta. In pathology, macrophages are key components of tissue repair and remodelling that occur during wound healing, allergy, parasite infection and cancer. Interaction with cells bearing stem or progenitor cell properties is likely an important component of the role of macrophages in repair and remodelling. These properties of cells of the monocyte-macrophage lineage may represent a tool and a target for therapeutic exploitation.read more
Citations
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Macrophage plasticity, polarization, and function in health and disease.
Abbas Shapouri-Moghaddam,Saeed Mohammadian,Hossein Vazini,Mahdi Taghadosi,Seyed-Alireza Esmaeili,Fatemeh Mardani,Bita Seifi,Asadollah Mohammadi,Jalil Tavakol Afshari,Amirhossein Sahebkar +9 more
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TL;DR: Schulz et al. as discussed by the authors investigated whether adult macrophages all share a common developmental origin and found that a population of yolk-sac-derived, tissue-resident macophages was able to develop and persist in adult mice in the absence of hematopoietic stem cells.
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Tissue-resident macrophages
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From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
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TL;DR: This review will address some of the important questions under the general framework of the role of monocytes and macrophages in the initiation, development, resolution, and chronicization of inflammation.
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Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.
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