Magnetic Resonance Imaging/Ultrasound-Fusion Biopsy Significantly Upgrades Prostate Cancer Versus Systematic 12-core Transrectal Ultrasound Biopsy

doi:10.1016/J.EURURO.2013.05.059

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Magnetic Resonance Imaging/Ultrasound-Fusion Biopsy Significantly Upgrades Prostate Cancer Versus Systematic 12-core Transrectal Ultrasound Biopsy

Journal Article•DOI•

Magnetic Resonance Imaging/Ultrasound-Fusion Biopsy Significantly Upgrades Prostate Cancer Versus Systematic 12-core Transrectal Ultrasound Biopsy

M. Minhaj Siddiqui¹, Soroush Rais-Bahrami¹, Hong Truong¹, Lambros Stamatakis¹, Srinivas Vourganti¹, Jeffrey W. Nix¹, Anthony N. Hoang¹, Annerleim Walton-Diaz¹, Brian Shuch¹, Michael Weintraub¹, Jochen Kruecker², Hayet Amalou¹, Baris Turkbey¹, Maria J. Merino¹, Peter L. Choyke¹, Bradford J. Wood¹, Peter A. Pinto¹ - Show less +13 more•Institutions (2)

National Institutes of Health¹, Philips²

01 Nov 2013-European Urology (Elsevier)-Vol. 64, Iss: 5, pp 713-719

TL;DR: MRI/US-fusion-guided biopsy upgrades and detects PCa of higher Gleason score in 32% of patients compared with traditional 12-core biopsy alone, and preferentially detects higher-grade PCa while missing lower-grade tumors.

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About: This article is published in European Urology.The article was published on 2013-11-01 and is currently open access. It has received 460 citations till now. The article focuses on the topics: Image-Guided Biopsy & Biopsy.

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Journal Article•DOI•

Comparison of MR/Ultrasound Fusion–Guided Biopsy With Ultrasound-Guided Biopsy for the Diagnosis of Prostate Cancer

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M. Minhaj Siddiqui¹, M. Minhaj Siddiqui², Soroush Rais-Bahrami¹, Soroush Rais-Bahrami³, Baris Turkbey¹, Arvin K. George¹, Jason Rothwax¹, Nabeel Shakir¹, Chinonyerem Okoro¹, Dima Raskolnikov¹, Howard L. Parnes¹, W. Marston Linehan¹, Maria J. Merino¹, Richard M. Simon¹, Peter L. Choyke¹, Bradford J. Wood¹, Peter A. Pinto¹ - Show less +13 more•Institutions (3)

National Institutes of Health¹, University of Maryland, Baltimore², University of Alabama at Birmingham³

27 Jan 2015-JAMA

TL;DR: Among men undergoing biopsy for suspected prostate cancer, targeted MR/ultrasound fusionBiopsy, compared with standard extended-sextant ultrasound-guided biopsy, was associated with increased detection of high-risk prostate cancer and decreased detection of low- risk prostate cancer.

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Abstract: Importance Targeted magnetic resonance (MR)/ultrasound fusion prostate biopsy has been shown to detect prostate cancer. The implications of targeted biopsy alone vs standard extended-sextant biopsy or the 2 modalities combined are not well understood. Objective To assess targeted vs standard biopsy and the 2 approaches combined for the diagnosis of intermediate- to high-risk prostate cancer. Design, setting, and participants Prospective cohort study of 1003 men undergoing both targeted and standard biopsy concurrently from 2007 through 2014 at the National Cancer Institute in the United States. Patients were referred for elevated level of prostate-specific antigen (PSA) or abnormal digital rectal examination results, often with prior negative biopsy results. Risk categorization was compared among targeted and standard biopsy and, when available, whole-gland pathology after prostatectomy as the "gold standard." Interventions Patients underwent multiparametric prostate magnetic resonance imaging to identify regions of prostate cancer suspicion followed by targeted MR/ultrasound fusion biopsy and concurrent standard biopsy. Main outcomes and measures The primary objective was to compare targeted and standard biopsy approaches for detection of high-risk prostate cancer (Gleason score ≥ 4 + 3); secondary end points focused on detection of low-risk prostate cancer (Gleason score 3 + 3 or low-volume 3 + 4) and the biopsy ability to predict whole-gland pathology at prostatectomy. Results Targeted MR/ultrasound fusion biopsy diagnosed 461 prostate cancer cases, and standard biopsy diagnosed 469 cases. There was exact agreement between targeted and standard biopsy in 690 men (69%) undergoing biopsy. Targeted biopsy diagnosed 30% more high-risk cancers vs standard biopsy (173 vs 122 cases, P Conclusions and relevance Among men undergoing biopsy for suspected prostate cancer, targeted MR/ultrasound fusion biopsy, compared with standard extended-sextant ultrasound-guided biopsy, was associated with increased detection of high-risk prostate cancer and decreased detection of low-risk prostate cancer. Future studies will be needed to assess the ultimate clinical implications of targeted biopsy. Trial registration clinicaltrials.gov Identifier: NCT00102544.

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1,291 citations

Journal Article•DOI•

Magnetic resonance imaging-targeted biopsy may enhance the diagnostic accuracy of significant prostate cancer detection compared to standard transrectal ultrasound-guided biopsy: a systematic review and meta-analysis.

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Ivo G. Schoots¹, Monique J. Roobol¹, Daan Nieboer¹, Chris H. Bangma¹, Ewout W. Steyerberg¹, M. G. Myriam Hunink² - Show less +2 more•Institutions (2)

Erasmus University Medical Center¹, Harvard University²

01 Sep 2015-European Urology

TL;DR: Evidence is found to suggest that MRI-guided targeted biopsy benefits the diagnosis of prostate cancer, and the comparison of MRI-TBx and TRUS-Bx needs to be regarded with caution.

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572 citations

Journal Article•DOI•

Prospective Study of Diagnostic Accuracy Comparing Prostate Cancer Detection by Transrectal Ultrasound–Guided Biopsy Versus Magnetic Resonance (MR) Imaging with Subsequent MR-guided Biopsy in Men Without Previous Prostate Biopsies

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Morgan Pokorny¹, Maarten de Rooij², Earl Duncan, Fritz H. Schröder³, Robert Parkinson¹, Jelle O. Barentsz², Leslie C. Thompson¹ - Show less +3 more•Institutions (3)

Wesley Hospital¹, Radboud University Nijmegen², Erasmus University Rotterdam³

01 Jul 2014-European Urology

TL;DR: Comparing the diagnostic efficacy of the magnetic resonance imaging (MRI) pathway with transrectal ultrasound-guided biopsy in men with elevated prostate-specific antigen found that mpMRI/MRGB reduces the detection of low-risk PCa and reduces the number of men requiring biopsy while improving the overall rate of detection of intermediate/high- risk PCa.

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499 citations

Journal Article•DOI•

Detection of Clinically Significant Prostate Cancer Using Magnetic Resonance Imaging–Ultrasound Fusion Targeted Biopsy: A Systematic Review

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Massimo Valerio¹, Massimo Valerio², Massimo Valerio³, Ian Donaldson², Mark Emberton¹, Mark Emberton², Behfar Ehdaie⁴, Boris Hadaschik⁵, Leonard S. Marks⁶, Pierre Mozer⁷, Ardeshir R. Rastinehad⁸, Hashim U. Ahmed², Hashim U. Ahmed¹ - Show less +9 more•Institutions (8)

University College London¹, University College London Hospitals NHS Foundation Trust², University Hospital of Lausanne³, Memorial Sloan Kettering Cancer Center⁴, University Hospital Heidelberg⁵, University of California, Los Angeles⁶, Pierre-and-Marie-Curie University⁷, Smith Institute⁸

01 Jul 2015-European Urology

TL;DR: Software-based MRI-US fusion targeted biopsy seems to detect more clinically significant cancers deploying fewer cores than standard biopsy, although further high-quality evidence is needed to change current practice.

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407 citations

Cites background from "Magnetic Resonance Imaging/Ultrasou..."

...Siddiqui et al [30] Paired cohort study 582 Mixed (55% previous negative biopsy) Mean " SD: 61....
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Journal Article•DOI•

Multifocality and Prostate Cancer Detection by Multiparametric Magnetic Resonance Imaging: Correlation with Whole-mount Histopathology

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Jesse D. Le¹, Nelly Tan¹, Eugene Shkolyar¹, David Y. Lu¹, Lorna Kwan¹, Leonard S. Marks¹, Jiaoti Huang¹, Daniel Margolis¹, Steven S. Raman¹, Robert E. Reiter¹ - Show less +6 more•Institutions (1)

University of California, Los Angeles¹

01 Mar 2015-European Urology

TL;DR: It is found that tumor size and grade were important predictors of tumor detection, and although cancer is often multifocal, MRI is often able to detect the worst focus of cancer.

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368 citations

Cites background or methods from "Magnetic Resonance Imaging/Ultrasou..."

...Results and limitations: The 122 patients had 283 unique histologically confirmed CaP tumor foci....
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...In this study, MRI performed well for higher-grade and larger tumors, with 72% sensitivity for CaP of Gleason 7 or tate Cancer Detection by Multiparametric Magnetic Resonance l (2014), http://dx.doi.org/10.1016/j.eururo.2014.08.079 Fig....
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...Multiparametric magnetic resonance imaging (mp-MRI) in prostate cancer (CaP) has demonstrated value in terms of increased cancer detection via targeted biopsy [1,2], decreased detection of indolent disease [3], and improved risk stratification [4], selection for active surveillance [5], clinical staging [6], prediction of biochemical recurrence [7], and surgical planning [8]....
[...]
...Eur Uro CaP; although they attributed 50% of pT2b cases to multifocality, no specific analysis was provided for the multifocal tumors....
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...Despite the multifocality of many CaPs, lethal metastatic CaP may be traceable to a single aberrant progenitor cell....
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References

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Open Access

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Journal Article•DOI•

Image-guided prostate biopsy using magnetic resonance imaging-derived targets: a systematic review.

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Caroline M. Moore¹, Caroline M. Moore², Nicola L. Robertson², Nasr Arsanious¹, Thomas Middleton¹, Arnauld Villers³, Laurence Klotz, Samir S. Taneja⁴, Mark Emberton² - Show less +5 more•Institutions (4)

Croydon University Hospital¹, University College London², university of lille³, New York University⁴

01 Jan 2013-European Urology

TL;DR: MRI-guided biopsy detects clinically significant prostate cancer in an equivalent number of men versus standard biopsy using fewer biopsies in fewer men, with a reduction in the diagnosis of clinically insignificant cancer.

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532 citations

"Magnetic Resonance Imaging/Ultrasou..." refers background in this paper

...The ability to detect, delineate, and measure PCa on magnetic resonance imaging (MRI) has led to the development of three MRI-guided prostate biopsy methods: cognitive fusion, direct MRI-guided biopsy, and several methods of MRI/ultrasound (MRI/US)-fusion-guided biopsy [7]....
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Journal Article•DOI•

Multiparametric 3T prostate magnetic resonance imaging to detect cancer: histopathological correlation using prostatectomy specimens processed in customized magnetic resonance imaging based molds

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Baris Turkbey¹, Haresh Mani¹, Vijay Shah¹, Vijay Shah², Ardeshir R. Rastinehad¹, Marcelino Bernardo¹, Marcelino Bernardo², Thomas J. Pohida³, Yuxi Pang⁴, Dagane Daar¹, Compton Benjamin¹, Yolanda McKinney¹, Hari Trivedi¹, Celene Chua¹, Gennady Bratslavsky¹, Joanna H. Shih¹, W. Marston Linehan¹, Maria J. Merino¹, Peter L. Choyke¹, Peter A. Pinto¹ - Show less +16 more•Institutions (4)

National Institutes of Health¹, Science Applications International Corporation², Center for Information Technology³, Philips⁴

01 Nov 2011-The Journal of Urology

TL;DR: Prostate magnetic resonance imaging at 3T allows for the detection of prostate cancer and a multiparametric approach increases the predictive power of magnetic resonance Imaging for diagnosis.

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"Magnetic Resonance Imaging/Ultrasou..." refers background in this paper

...Lesions identified on MP-MRI correlate with tumor location on radical prostatectomy specimens [5]....
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Journal Article•DOI•

Prostate cancer: value of multiparametric MR imaging at 3 T for detection--histopathologic correlation.

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Baris Turkbey¹, Peter A. Pinto¹, Haresh Mani¹, Marcelino Bernardo¹, Yuxi Pang¹, Yuxi Pang², Yolanda McKinney¹, Kiranpreet Khurana¹, Gregory Ravizzini¹, Paul S. Albert¹, Maria J. Merino¹, Peter L. Choyke¹ - Show less +8 more•Institutions (2)

National Institutes of Health¹, Philips²

10 Mar 2010-Radiology

TL;DR: Multiparametric MR imaging of the prostate at 3 T enables tumor detection, with reasonable sensitivity and specificity values, and Generalized estimating equations (GEEs) provided significant independent and additive predictive value when GEEs were used.

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Abstract: Combined use of anatomic (T2-weighted MR imaging) and functional (MR spectroscopy and dynamic contrast material–enhanced MR imaging) modalities improves the performance of MR imaging for prostate tumor detection.

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447 citations

Additional excerpts

..., Pittsburgh, PA, USA), as previously described [10,11]....
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Journal Article•DOI•

Magnetic Resonance Imaging/Ultrasound Fusion Guided Prostate Biopsy Improves Cancer Detection Following Transrectal Ultrasound Biopsy and Correlates With Multiparametric Magnetic Resonance Imaging

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Peter A. Pinto¹, Paul H. Chung¹, Ardeshir R. Rastinehad¹, Angelo A. Baccala Md¹, Jochen Kruecker², Compton Benjamin¹, Sheng Xu², Pingkun Yan², Samuel Kadoury², Celene Chua¹, Julia K. Locklin¹, Baris Turkbey¹, Joanna H. Shih², Stacey P. Gates¹, Carey Buckner¹, Gennady Bratslavsky¹, W. Marston Linehan¹, Neil Glossop¹, Peter L. Choyke¹, Bradford J. Wood¹ - Show less +16 more•Institutions (2)

National Institutes of Health¹, Philips²

01 Oct 2011-The Journal of Urology

TL;DR: Prostate cancer localized on magnetic resonance Imaging may be targeted using this novel magnetic resonance imaging/ultrasound fusion guided biopsy platform, and to determine which patients may benefit.

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435 citations

"Magnetic Resonance Imaging/Ultrasou..." refers background or methods in this paper

...An initial cohort in this same clinical trial previously demonstrated that MRI/US-fusion-guided targeted biopsy increased cancer detection rates significantly compared with standard 12-core TRUS biopsy alone, especially in lesions with a high level of suspicion on the MRI [12]....
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...Subjects with lesions suspicious for PCa on MP-MRI underwent prostate biopsy as previously described [12]....
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Journal Article•DOI•

Standards of Reporting for MRI-targeted Biopsy Studies (START) of the Prostate: Recommendations from an International Working Group.

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Caroline M. Moore¹, Veeru Kasivisvanathan¹, Scott E. Eggener², Mark Emberton¹, Jurgen J. Fütterer³, Inderbir S. Gill⁴, Robert L. Grubb⁵, Boris Hadaschik⁶, Laurence Klotz⁷, Daniel Margolis⁸, Leonard S. Marks⁸, Jonathan Melamed⁹, Aytekin Oto², Suzanne L. Palmer⁴, Peter A. Pinto¹⁰, Philippe Puech¹¹, Shonit Punwani¹, Andrew B. Rosenkrantz⁹, Ivo G. Schoots¹², Richard Simon¹⁰, Samir S. Taneja⁹, Baris Turkbey¹⁰, Osamu Ukimura⁴, Jan van der Meulen¹³, Arnauld Villers¹¹, Yuji Watanabe - Show less +22 more•Institutions (13)

University College London¹, University of Chicago², Radboud University Nijmegen Medical Centre³, University of Southern California⁴, Washington University in St. Louis⁵, University Hospital Heidelberg⁶, Sunnybrook Health Sciences Centre⁷, University of California, Los Angeles⁸, New York University⁹, National Institutes of Health¹⁰, university of lille¹¹, Erasmus University Rotterdam¹², University of London¹³

01 Oct 2013-European Urology

TL;DR: Use of the START checklist would improve the quality of reporting in MRI-targeted biopsy studies and facilitate a comparison between standard and MRI- targeted approaches.

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399 citations

"Magnetic Resonance Imaging/Ultrasou..." refers background or methods in this paper

...The cohort was divided into clinically significant high-grade (Gleason score 4 + 3) and clinically insignificant low-grade (Gleason score 3 + 4) subcohorts in accordance with the Standards of Reporting for MRI-targeted Biopsy Studies (START) working group recommendations [13]....
[...]
...Although core length was not incorporated into the definitions of clinically significant and insignificant disease in this study, which was focused on Gleason score upgrading, maximum cancercore length has been recommended by experts as an important variable to incorporate into the measure of clinical significance of PCa [13]....
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