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Maintenance of sinus rhythm after DC reversion of atrial fibrillation: A double-blind controlled trial of long-acting quinidine bisulphate

Edward Byrne-Quinn, +1 more
- 01 May 1970 - 
- Vol. 32, Iss: 3, pp 370-376
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TLDR
The maintenance of sinus rhythm in the treated group was significantly longer than in the control group, especially during the first three months, especially after DC reversion of atrial fibrillation.
Abstract
Ninety-two patients were entered in a double-blind controlled trial of long-acting quinidine bisulphate for the maintenance of sinus rhythm following DC reversion of atrial fibrillation. By random selection two statistically comparable groups of patients were obtained, a control group being given a placebo and a treated group quinidine bisulphate 1·5 g. per day in two 12-hourly doses. Thirty-seven patients were followed up in the control group and twenty-eight patients in the treated group. The maintenance of sinus rhythm in the treated group was significantly longer than in the control group, especially during the first three months. The mean serum quinidine level in the treated group was 2·2±0·3 (SEM) mg. per litre. There was one death among the patients treated with quinidine, which may have been due to quinidine toxicity caused by a high serum quinidine level.

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Citations
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Journal ArticleDOI

2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

TL;DR: This guideline was developed in conjunction with the European Society of Cardiology (ESC) and aims to improve the effectiveness of care, optimize patient outcomes, and favorably affect the overall cost of care by focusing resources on the most effective strategies.
Journal ArticleDOI

Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials.

TL;DR: Quinidine treatment is more effective than no antiarrhythmic therapy in suppressing recurrences of atrial fibrillation but appears to be associated with increased total mortality.
References
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Journal ArticleDOI

New method for terminating cardiac arrhythmias. Use of synchronized capacitor discharge.

TL;DR: Since it is impossible in any one patient to predict either the effective or the toxic dose, small increments of antiarrhythmic drugs are given at frequent intervals until a therapeutic end point is reached.
Journal ArticleDOI

Electrical reversion of cardiac arrhythmias.

B Lown
- 01 Jul 1967 - 
Journal ArticleDOI

Management of patients with atrial fibrillation

TL;DR: In the use of quinidine sulfate to revert atrial fibrillation to normal sinus rhythm, large dosage schedules are no longer justified if a direct current synchronized defibrillator is available and should be allowed to continue and to control the ventricular rate with digitalis rather than risk the dangers ofQuinidine toxicity.
Journal Article

The estimation of quinine in human plasma with a note on the estimation of quinidine

TL;DR: A simple precise method is described for the estimation of quinine in human plasma by measuring the intensity of its fluorescence in ultraviolet light.
Journal ArticleDOI

Experience with "cardioversion" of atrial fibrillation and flutter.

TL;DR: Synchronized direct current countershock was used in 70 patients on 94 occasions for reversion of atrial fibrillation or flutter, with high degree of acute success, low incidence of complications, and success in maintaining sinus rhythm for a short follow-up period.
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