Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ.
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...…Yanagisawa) coding Galβ1,4(Fucα1,3)GlcNAcβ1- (Yu and Yanagisawa 2006), while O-mannosylation is also a significant feature of α-dystroglycan in the nervous system, where it mediates cell-extracellular matrix contact (Hennet 2009; Panin and Wells 2014; Praissman and Wells 2014; Yaji et al. 2015)....
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...Neural stem cells express CD15 (Yu and Yanagisawa) coding Galβ1,4(Fucα1,3)GlcNAcβ1- (Yu and Yanagisawa 2006), while O-mannosylation is also a significant feature of α-dystroglycan in the nervous system, where it mediates cell-extracellular matrix contact (Hennet 2009; Panin and Wells 2014; Praissman and Wells 2014; Yaji et al. 2015)....
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...We confirmed already known LeX presenting proteins such as phosphacan, tenascin-C, and L1-CAM (Garwood et al., 1999; Hennen et al., 2013; Streit et al., 1990; Yaji et al., 2015)....
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45 citations
References
2,445 citations
"Major glycan structure underlying e..." refers methods in this paper
...COS-1 cells were purchased from American Type Culture Collection (ATCC CRL-1650) (Gluzman 1981)....
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2,376 citations
"Major glycan structure underlying e..." refers background in this paper
...Moreover, these "specific glycosylations" have been shown to determine the functionality of the carrier glycoproteins (Kleene and Schachner 2004; Ohtsubo and Marth 2006)....
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1,756 citations
"Major glycan structure underlying e..." refers background in this paper
...Glycosylation is one of the most frequent post-translational modifications of proteins (Apweiler et al. 1999)....
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685 citations
"Major glycan structure underlying e..." refers background or methods in this paper
...…known to be biosynthesized by the first enzyme POMT (Beltran-Valero de Bernabe et al. 2002), and N-acetylglucosamine at O ndokuz M ayis U niversity on N ovem ber 12, 2014 http://glycob.oxfordjournals.org/ D ow nloaded from (GlcNAc) could be transferred to O-mannose by POMGnT1 (Yoshida et al. 2001)....
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...1997) and was synthesized by protein O-mannosyl transferase 1 (POMT1), POMT2, and protein O-mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (Yoshida et al. 2001; Manya et al. 2004)....
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...Mutations in the genes encoding POMT1/2 and POMGnT1 have been shown to cause muscular dystrophies with abnormal -DG glycosylation, designated as Walker-Warburg syndrome and muscle-eye-brain disease, respectively (Yoshida et al. 2001; Beltran-Valero de Bernabe et al. 2002; van Reeuwijk et al. 2005)....
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...…(Siaα2-3Galβ1-4GlcNAcβ1-2Man) was discovered in bovine peripheral nerve α-dystroglycan (α-DG) (Chiba et al. 1997) and was synthesized by protein O-mannosyl transferase 1 (POMT1), POMT2, and protein O-mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (Yoshida et al. 2001; Manya et al. 2004)....
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...(GlcNAc) could be transferred to O-mannose by POMGnT1 (Yoshida et al. 2001)....
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645 citations
"Major glycan structure underlying e..." refers background in this paper
...Mutations in the genes encoding POMT1/2 and POMGnT1 have been shown to cause muscular dystrophies with abnormal -DG glycosylation, designated as Walker-Warburg syndrome and muscle-eye-brain disease, respectively (Yoshida et al. 2001; Beltran-Valero de Bernabe et al. 2002; van Reeuwijk et al. 2005)....
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...O-mannosyl glycans are known to be biosynthesized by the first enzyme POMT (Beltran-Valero de Bernabe et al. 2002), and N-acetylglucosamine at O ndokuz M ayis U niversity on N ovem ber 12, 2014 http://glycob.oxfordjournals.org/ D ow nloaded from (GlcNAc) could be transferred to O-mannose by POMGnT1…...
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