Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ.
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...…Yanagisawa) coding Galβ1,4(Fucα1,3)GlcNAcβ1- (Yu and Yanagisawa 2006), while O-mannosylation is also a significant feature of α-dystroglycan in the nervous system, where it mediates cell-extracellular matrix contact (Hennet 2009; Panin and Wells 2014; Praissman and Wells 2014; Yaji et al. 2015)....
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...Neural stem cells express CD15 (Yu and Yanagisawa) coding Galβ1,4(Fucα1,3)GlcNAcβ1- (Yu and Yanagisawa 2006), while O-mannosylation is also a significant feature of α-dystroglycan in the nervous system, where it mediates cell-extracellular matrix contact (Hennet 2009; Panin and Wells 2014; Praissman and Wells 2014; Yaji et al. 2015)....
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...We confirmed already known LeX presenting proteins such as phosphacan, tenascin-C, and L1-CAM (Garwood et al., 1999; Hennen et al., 2013; Streit et al., 1990; Yaji et al., 2015)....
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45 citations
References
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"Major glycan structure underlying e..." refers background in this paper
...A recent study suggested that Lewis X is involved in regulating neural stem cells via the Notch signaling pathway (Yagi et al. 2012)....
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49 citations
"Major glycan structure underlying e..." refers background in this paper
...Knockout (KO) mice for beta-1, 4-galactosyltransferase2 (β4GalT2) and POMGnT1 were described previously (Miyagoe-Suzuki et al. 2009; Yoshihara et al. 2009)....
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44 citations
"Major glycan structure underlying e..." refers background in this paper
...A recent mass spectrometric analysis revealed that, in the mouse brain, the existence of sialyl Lewis X was quite small among the entire Lewis X-related structures (Parry et al. 2007)....
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44 citations
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...Mutations in the genes encoding POMT1/2 and POMGnT1 have been shown to cause muscular dystrophies with abnormal -DG glycosylation, designated as Walker-Warburg syndrome and muscle-eye-brain disease, respectively (Yoshida et al. 2001; Beltran-Valero de Bernabe et al. 2002; van Reeuwijk et al. 2005)....
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41 citations
"Major glycan structure underlying e..." refers background in this paper
...…ber 12, 2014 http://glycob.oxfordjournals.org/ D ow nloaded from unchanged in the myodystrophy (myd) mouse, in which like-acetylglucosaminyltransferase (LARGE), a responsible enzyme for the extension of the disaccharide repeats in the post-phosphoryl modification, was mutated (Dwyer et al. 2012)....
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