Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
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...Caspases are highly conserved through evolution, and can be found from humans all the way down to insects, nematodes and hydr...
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...…focuses on the latest developments and surveys our current un- The P1 residue (Asp) is coordinated by three invariant residues at the S1 site, an Arg from L1, a Gln at thederstanding of caspase regulation at a molecular level. beginning of L2, and an Arg at the end of L3 (Earnshaw et al., 1999)....
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...…the 14 caspases play important roles during apoptosis is mediated by hydrophobic interactions, with 6 antipar(Budihardjo et al., 1999; Earnshaw et al., 1999; Fesik allel strands from each catalytic subunit forming a and Shi, 2001; Salvesen and Dixit, 1997; Thornberry and single…...
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