Manufacture of gluconic acid: A review towards process intensification for green production
TL;DR: A comprehensive review of the critical aspects of production of gluconic acid suggests ways towards development of green processes through process intensification leading to the prospects of sustainable business.
Abstract: In view of the huge application potential of gluconic acid and its derivatives, this manuscript critically reviews literature of the last thirty years on evolution of production processes of this important organic acid for the purpose of directing further research towards process intensification for innovative green processes. Fermentative process and catalytic oxidation are found to be the two basic approaches in production of gluconic acid. In both the approaches, downstream purification involves several steps such as centrifugation, carbon adsorption, evaporation, crystallization and ion-exchange. Cost-effective and eco-friendly production of high purity gluconic acid has remained a challenge, mainly due to involvement of multiple downstream processing units and their associated energy consumption and cost factors. In the recent years, possibility of integration of tailor-made and highly selective membranes and modules with fermenter in downstream purification of gluconic acid appears to have brightened the prospects of gluconic acid manufacture. This paper through a comprehensive review of the critical aspects of production of gluconic acid suggests ways towards development of green processes through process intensification leading to the prospects of sustainable business.
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TL;DR: Recent advances and developments in catalytic transformations of the carbohydrate content of lignocellulosic biomass to IPCs (i.e., ethanol, 3-hydroxypropionic acid, isoprene, succinic and levulinic acids, furfural, and 5-hydroxymethylfurfural) are overviewed.
Abstract: The replacement of fossil resources that currently provide more than 90% of our energy needs and feedstocks of the chemical industry in combination with reduced emission of carbon dioxide is one of the most pressing challenges of mankind. Biomass as a globally available resource has been proposed as an alternative feedstock for production of basic building blocks, which could partially or even fully replace the currently utilized fossil-based ones in well-established chemical processes. The destruction of lignocellulosic feed followed by oxygen removal from its cellulose and hemicellulose content by catalytic processes results in the formation of initial platform chemicals (IPCs). However, their sustainable production strongly depends on the availability of resources, their efficient or even industrially viable conversion processes, and replenishment time of feedstocks. Herein, we overview recent advances and developments in catalytic transformations of the carbohydrate content of lignocellulosic biomass ...
784 citations
TL;DR: Examining the properties of gluconic acid and its derivatives and their uses and production methods, especially biotechnological methods, are examined to update the existing reviews on the topic.
119 citations
TL;DR: In this article, a review describes innovative methods of enhancing fungal glucose oxidase (GOD) production by using genetic and non-genetic approaches in-depth along with purification techniques.
Abstract: Fungal glucose oxidase (GOD) is widely employed in the different sectors of food industries for use in baking products, dry egg powder, beverages, and gluconic acid production. GOD also has several other novel applications in chemical, pharmaceutical, textile and other biotechnological industries. The electrochemical suitability of GOD catalyzed reactions has enabled its successful use in bioelectronic devices, particularly biofuel cells, and biosensors. Other crucial aspects of GOD such as improved feeding efficiency in response to GOD supplemental diet, roles in antimicrobial activities and enhancing pathogen defense response, thereby providing induced resistance in plants have also been reported. Moreover, the medical science, another emerging branch where GOD was recently reported to induce several apoptosis characteristics as well as cellular senescence by downregulating Klotho gene expression. These widespread applications of GOD have led to increased demand for more extensive research to improve its production, characterization, and enhanced stability to enable long term usages. Currently, GOD is mainly produced and purified from Aspergillus niger and Penicillium species, but the yield is relatively low and the purification process is troublesome. It is practical to build an excellent GOD-producing strain. Therefore, the present review describes innovative methods of enhancing fungal GOD production by using genetic and non-genetic approaches in-depth along with purification techniques. The review also highlights current research progress in the cost effective production of GOD, including key advances, potential applications and limitations. Therefore, there is an extensive need to commercialize these processes by developing and optimizing novel strategies for cost effective GOD production.
76 citations
Cites background from "Manufacture of gluconic acid: A rev..."
...Sodium gluconate has great potential to chelate metal ions and can be used to remove bitterness from food stuff (Costa et al., 2015; Pal et al., 2016)....
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...GA can be produced through biochemical, electrochemical, bioelectrochemical, and fermentative processes, although fermentative processes are preferred for GA production as other approaches are expensive and less productive (Wong et al., 2008; Pal et al., 2016)....
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...However, these hurdles can be resolved by membrane-based separation (Pal et al., 2016)....
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01 Jan 2019
TL;DR: This chapter provides an overview of industrially important microbial enzymes; particularly their sources and applications, and the screening of novel enzymes that are capable of catalyzing new reactions is constantly required.
Abstract: People have exploited the biocatalytic potential of microorganisms for centuries to produce wine, vinegar, bread, and so forth without understanding their biochemical basis. Microbial enzymes are also used as biocatalysts in various industrial processes in an economical and environmentally-friendly way, as compared with chemical catalysis. Over the past few decades, the use of microbial enzymes in bioprocesses has increased rapidly, because of their catalytic activity, as well as stability. Worldwide, enzymes produced from microorganisms have been extensively investigated for isolation, purification, characterization, and applications. Microbial enzymes have diverse applications in the food, pharmaceutical, and biotechnological industries, and so forth. Commercially, many recombinant enzymes from bacteria and fungi are used in various bioprocesses. Modern techniques such as metagenomics and genomics can be used to discover new microbial enzymes, whose catalytic properties can be improved further using molecular techniques. Moreover, the screening of novel enzymes that are capable of catalyzing new reactions is constantly required. The discovery of new enzymes will provide clues for the design of new enzymatic processes. This chapter provides an overview of industrially important microbial enzymes; particularly their sources and applications.
71 citations
TL;DR: This review presents many different cascade reactions and discusses the advantages/drawbacks of the use of co-immobilized enzymes in the production of D-gluconic acid.
61 citations
References
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01 Jan 1994TL;DR: Solid-state fermentation has emerged as a potential technology for the production of microbial products such as feed, fuel, food, industrial chemicals and pharmaceutical products and with continuity in current trends, SSF technology would be well developed at par with submerged fermentation technology in times to come.
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1,431 citations
TL;DR: Nanofiltration (NF) membranes have come a long way since it was first introduced during the late 80's as mentioned in this paper, and significant development has taken place in terms of the fundamental understanding of the transport mechanism in NF membranes, which has been translated into predictive modeling based on the modified extended Nernst-Planck equation.
1,374 citations
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1,059 citations
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948 citations
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Trending Questions (1)
What problem does research of gluconic acid production seek to solve?
The research on gluconic acid production seeks to solve the challenges of cost-effectiveness and eco-friendliness in downstream purification processes.