Mapping brain circuitry with a light microscope.
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Cites background from "Mapping brain circuitry with a ligh..."
...As part of the effort to chart long-range connectivity in the mouse brain (Marx, 2012; Osten and Margrie, 2013; Pollock et al., 2014), we launched the Mouse Connectome Project (MCP, www.MouseConnectome.org)....
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...In conclusion, we and other groups have demonstrated the feasibility of producing and collecting large-scale connectivity data (Osten and Margrie, 2013; Pollock et al., 2014); however, interpretation of this wealth of anatomical data presents an ongoing challenge....
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Cites methods from "Mapping brain circuitry with a ligh..."
...Wholebrain imaging using high-resolution light sheet microscopy or other advanced imaging methods will allow for the classification of cell-type-specific tracing, including integrity of axonal pathways and detailed neuronal morphology (Chung et al., 2013; Osten and Margrie, 2013)....
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References
15,681 citations
"Mapping brain circuitry with a ligh..." refers methods in this paper
...…for standardized digital atlasing (Hawrylycz et al., 2011) allows comparisons of registered mouse brain data using multiple brain atlases, including the Allen Mouse Brain Atlas, the digital Paxinos and Franklin Mouse Brain Atlas (Paxinos and Franklin, 2004), and several MRI reference mouse brains....
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...In addition, the so-called Waxholm space (WHS) for standardized digital atlasing (Hawrylycz et al., 2011) allows comparisons of registered mouse brain data using multiple brain atlases, including the Allen Mouse Brain Atlas, the digital Paxinos and Franklin Mouse Brain Atlas (Paxinos and Franklin, 2004), and several MRI reference mouse brains....
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8,905 citations
"Mapping brain circuitry with a ligh..." refers methods in this paper
...…to achieve submicron resolution close to the diffraction limits of LM.1 Three instruments have been designed that combine two-photon microscopy (Denk et al., 1990) followed by tissue sectioning by either ultra-short laser pulses in all-optical histology (Tsai et al., 2003), milling machine in…...
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7,796 citations
5,365 citations
"Mapping brain circuitry with a ligh..." refers background or methods in this paper
..., 2008) can now be generated by imaging cell-typespecific Cre knock-in mouse lines (Madisen et al., 2010; Taniguchi et al., 2011) crossed with Credependent reporter mice expressing nuclear GFP....
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...Brain-region and cell-type specificity for mapping connectivity by the modified RV system can be achieved by using a Cre recombinase–dependent helper virus driving expression of TVA and RV-G and transgenic mouse lines that express Cre in specific cell types or cortical layers (Madisen et al., 2010; Wall et al., 2010; Taniguchi et al., 2011)....
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4,944 citations