Journal ArticleDOI
Markers of Neuroinflammation and Apoptosis in the Temporal Lobe of Patients with Drug-Resistant Epilepsy
A. V. Litovchenko,Yu. M. Zabrodskaya,D. A. Sitovskaya,L. K. Khuzhakhmetova,V. G. Nezdorovina,E. D. Bazhanova +5 more
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TLDR
In this paper, the level of pro-and anti-apoptotic proteins (p-NF-kB, TNF-α, p53, FAS, caspase-3, Caspase 9) was analyzed in intraoperative biopsies of the temporal lobe gray and white matter in the brain of patients with drug-resistant epilepsy.Abstract:
Current antiepileptic strategies aim to normalize the interaction
of the excitatory and inhibitory systems, which is ineffective in
treating patients with drug-resistant epilepsy. Neuroinflammatory processes
in the epileptic focus and its perifocal area can trigger apoptosis
and also contribute to the development of drug resistance. The level
of pro- and anti-apoptotic proteins (p-NF-kB, TNF-α, p53, FAS, caspase-3,
caspase-9) was analyzed in intraoperative biopsies of the temporal
lobe gray and white matter in the brain of patients with drug-resistant
epilepsy. An increased level of pro-apoptotic proteins was revealed
in the cortex and perifocal area’s white matter against the background
of an imbalance of protective anti-apoptotic proteins. It appears
that the activation of the extrinsic pathway of apoptosis occurs
in the perifocal area, while in the epileptic focus, there are proteins
responsible for the activation of the anti-apoptotic survival pathways.
Active neuroinflammation in the epileptic focus and perifocal area
of the temporal lobe may contribute to the development of the resistance
to antiepileptic drugs and the progression of neurodegeneration in
such patients.read more
Citations
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Journal ArticleDOI
Relationship between Neuroglial Apoptosis and Neuroinflammation in the Epileptic Focus of the Brain and in the Blood of Patients with Drug-Resistant Epilepsy
Tatiana V. Sokolova,Yu M Zabrodskaya,A. V. Litovchenko,Nataly M Paramonova,V. Kasumov,S.V. Kravtsova,E. N. Skiteva,Daria Sitovskaya,E. D. Bazhanova +8 more
TL;DR: A comprehensive analysis of revealed changes in the blood and brain in DRE patients showed the neuroinflammation in the epileptic focus, which was combined with the development of apoptosis of glial cells and neurons, which creates conditions for theDevelopment of drug resistance and the epilepsy progression.
Book ChapterDOI
Epileptic Focus in Drug-Resistant Epilepsy: Structure, Organization, and Pathophysiology
TL;DR: In this article , different cutting-edge techniques can be used to study electrophysiological, pathomorphological, and biochemical changes in the epileptic focus area of the cerebral cortex and white matter to see how epileptic seizures become drug-resistant and how it affects the other regions of the brain.
Journal ArticleDOI
Glioneuronal apoptosis and neuroinflammation in drug resistant temporal lobe epilepsy
T. V. Sokolova,A. V. Litovchenko,Nataly M Paramonova,V. Kasumov,S.V. Kravtsova,V. G. Nezdorovina,Daria Sitovskaya,E. N. Skiteva,E. D. Bazhanova,Yu M Zabrodskaya +9 more
TL;DR: In this article , the authors evaluated pathological changes and structural signs of apoptosis, levels of apoptotic and pro-inflam-matory factors such as caspase-3, caspases-9, FAS, fas ligand (FAS-L), tumor necrosis factor α (TNFα), p53, nuclear factor κB (NF-κB), and Western blot (WB) for 30 patients with focal drug-resistant epilepsy.
References
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Journal ArticleDOI
Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study.
TL;DR: Overall outcomes in newly diagnosed epilepsy have not improved and most patients who attain control do so with the first or second AED, although the probability of achieving seizure freedom diminishes substantially with each subsequent AED regimen tried.
Journal ArticleDOI
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
Brandon J. Aubrey,Gemma L. Kelly,Gemma L. Kelly,Ana Janic,Ana Janic,Marco J Herold,Marco J Herold,Andreas Strasser,Andreas Strasser +8 more
TL;DR: Current understanding of the mechanisms by which p53 induces cell death is discussed and how this affects p53-mediated tumour suppression and the response of malignant cells to anticancer therapy is discussed.
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Journal ArticleDOI
The role of inflammation in the development of epilepsy
Amna Z Rana,Alberto E. Musto +1 more
TL;DR: Understanding the neurobiology of inflammation in epileptogenesis will contribute to the development of new biomarkers for better screening of patients at risk for epilepsy and new therapeutic targets for both prophylaxis and treatment of epilepsy.
Journal ArticleDOI
Complications of epilepsy surgery—A systematic review of focal surgical resections and invasive EEG monitoring
Walter Hader,Jose F. Tellez-Zenteno,Amy Metcalfe,Lisbeth Hernandez-Ronquillo,Samuel Wiebe,Samuel Wiebe,Churl-Su Kwon,Nathalie Jette,Nathalie Jette +8 more
TL;DR: The purpose of this study was to systematically review the literature on complications of focal epilepsy surgery and to correct physicians' misconceptions about the risks associated with epilepsy surgery.
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