Journal ArticleDOI
Mass spectral analysis in the identification of human metabolites of warfarin
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This article is published in Journal of Medicinal Chemistry.The article was published on 1970-11-01. It has received 77 citations till now.read more
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Journal ArticleDOI
Human P450 metabolism of warfarin.
TL;DR: The anticoagulant drug warfarin occurs as a pair of enantiomers that are differentially metabolized by human cytochromes P450 (CYP) and is affected primarily when metabolism of S-warfarin is altered.
Journal ArticleDOI
Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.
TL;DR: Overall, the CYP2C9 isoenzyme appears to be most important for the clearance of warfarin, followed by acenocoumarol and, lastly, phenprocoumon; this drug seems preferable for therapeutic anticoagulation in poor metabolisers of CYP1C9.
Journal ArticleDOI
Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE
Richard J. Lewis,William Trager,Kenneth K. Chan,A. Breckenridge,M. Orme,Malcolm Roland,William Schary +6 more
TL;DR: It is concluded that inhibition of the metabolism of S warfarin provides one mechanism for the augmented anticoagulation which follows phenylbutazone.
Journal ArticleDOI
Synthesis and structure-activity relationships of novel warfarin derivatives.
TL;DR: It is hypothesized that 4-Hydroxycoumarins bind to the active site of VKER thereby mimicking the transition state of the elimination of water from substrate 2-hydroxyvitamin K.
Journal ArticleDOI
Pharmacogenetics of oral anticoagulants: a basis for dose individualization
TL;DR: Despite the clear effects of CYP2C9 and VKORC1 variants, these polymorphisms explain less than half of the interindividual variability in the dose response to oral anticoagulants, while individuals at the extremes of the dose requirements are likely to benefit, the overall clinical merits of a genotype-adapted antICOagulant treatment regimen remain to be determined in further prospective clinical studies.
Related Papers (5)
Warfarin metabolism in man: identification of metabolites in urine
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Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man*
D S Hewick,John Mcewen +1 more