Matrix elasticity directs stem cell lineage specification.
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"Matrix elasticity directs stem cell..." refers background in this paper
...…Sweeney,1 and Dennis E. Discher1,2,3,4,* 1Pennsylvania Muscle Institute 2School of Engineering and Applied Science 3Cell & Molecular Biology Graduate Group 4Physics Graduate Group University of Pennsylvania, Philadelphia, PA 19104, USA *Contact: discher@seas.upenn.edu DOI 10.1016/j.cell.2006.06.044...
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...…or matrix microenvironments can be as physically diverse as those of brain, muscle, and bone precursor osteoid (respectively, Flanagan et al. 2002; Georges et al., 2006; Kondo et al., 2005, Engler et al., 2004a; Ferrari et al., 1998; Andrades et al., 2001; Holmbeck et al., 1999; Morinobu et al.,…...
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670 citations
"Matrix elasticity directs stem cell..." refers background in this paper
...…Sweeney,1 and Dennis E. Discher1,2,3,4,* 1Pennsylvania Muscle Institute 2School of Engineering and Applied Science 3Cell & Molecular Biology Graduate Group 4Physics Graduate Group University of Pennsylvania, Philadelphia, PA 19104, USA *Contact: discher@seas.upenn.edu DOI 10.1016/j.cell.2006.06.044...
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...This pulling or contractility by cells can be measured as a mean cellular prestress, s, that balances the traction stresses, t, exerted on the gel by the cell (Wang et al., 2002) (Figure 7)....
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...(McBeath et al., 2004; Wang et al., 2002)....
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654 citations
"Matrix elasticity directs stem cell..." refers background in this paper
...Importantly, transcriptional profiles of early versus late MSCs (up to passage 12) do not differ significantly (Table S1), even though population expansion has been suggested by others to dramatically alter MSCs (Maitra et al., 2005)....
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622 citations
"Matrix elasticity directs stem cell..." refers background in this paper
...Efficacy appears uncertain or mixed (Murry et al., 2004), and recent findings have raised the possibility that the injured microenvironment loses compliance with fibrotic scarring, producing a noninducing environment (Berry et al., 2006) that, as we show here, stem cells cannot sufficiently remodel....
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..., 2004), and recent findings have raised the possibility that the injured microenvironment loses compliance with fibrotic scarring, producing a noninducing environment (Berry et al., 2006) that, as we show here, stem cells cannot sufficiently remodel....
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617 citations
"Matrix elasticity directs stem cell..." refers background in this paper
...…Sweeney,1 and Dennis E. Discher1,2,3,4,* 1Pennsylvania Muscle Institute 2School of Engineering and Applied Science 3Cell & Molecular Biology Graduate Group 4Physics Graduate Group University of Pennsylvania, Philadelphia, PA 19104, USA *Contact: discher@seas.upenn.edu DOI 10.1016/j.cell.2006.06.044...
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...The matrix is 350 ± 100 nm thick (Figure 2F) and has a stiffness, Eosteoid 27 ± 10 kPa (Figure 2G), that is similar to a concentrated collagen gel (Roeder et al., 2002)....
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