Matrix-embedded cells control osteoclast formation
Jinhu Xiong,Melda Onal,Robert L. Jilka,Robert S. Weinstein,Stavros C. Manolagas,Charles A. O'Brien +5 more
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It is demonstrated that hypertrophic chondrocytes and osteocytes, both of which are embedded in matrix, are essential sources of the RANKL that controls mineralized cartilage resorption and bone remodeling, respectively.Abstract:
To date, the dogma in the field has been that RANKL, an essential cytokine in osteoclast maturation, is released by osteoblasts as a way to coordinate bone growth and bone loss during adult bone remodeling. Now, Hiroshi Takayanagi and colleagues, as well as Charles O'Brien and colleagues, have independently found that osteocytes are the predominant source of RANKL in the adult mouse. As RANKL signaling is a key target in treating osteoporosis, these results have potentially important implications for disease management.read more
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Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research
Elizabeth Shane,David B. Burr,Peter R. Ebeling,Bo Abrahamsen,Robert A. Adler,Thomas D. Brown,Angela M. Cheung,Felicia Cosman,Jeffrey R. Curtis,Richard M. Dell,David W. Dempster,Thomas A. Einhorn,Harry K. Genant,Piet Geusens,Klaus Klaushofer,Kenneth J. Koval,Joseph M. Lane,Fergus McKiernan,Ross E. McKinney,Alvin Choong Meng Ng,Jeri W. Nieves,Regis J. O'Keefe,Socrates E. Papapoulos,Howe Tet Sen,Marjolein C. H. van der Meulen,Robert S. Weinstein,Michael P. Whyte +26 more
TL;DR: This newer evidence suggests that AFFs are stress or insufficiency fractures, and studies with radiographic review consistently report significant associations between A FFs and BP use, although the strength and magnitude of effect vary.
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WNT signaling in bone homeostasis and disease: from human mutations to treatments
Roland Baron,Michaela Kneissel +1 more
TL;DR: Current understanding of the mechanisms by which WNT signalng regulates bone homeostasis is reviewed, finding the pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture.
Book
Skeletal Tissue Mechanics
TL;DR: This poster presents a probabilistic procedure for estimating the mechanical properties of bone based on known mechanisms, including compressive forces, compressive strength, and the compressive properties of Bone.
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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Rinaldo Florencio-Silva,Gisela Rodrigues da Silva Sasso,Estela Sasso-Cerri,Manuel Simões,Paulo Sérgio Cerri +4 more
TL;DR: Current data about the structure and functions of bone cells and the factors that influence bone remodeling are discussed, indicating the dynamic nature of bone tissue.
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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
TL;DR: The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange, which will result in a more complete understanding of VDR coactivator interactions, thus facilitating cell and gene specific clinical applications.
References
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Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
David L. Lacey,Emma Timms,Hong-Lin Tan,Michael J. Kelley,Colin R. Dunstan,Tim Burgess,Robin Elliott,Anne Colombero,Gary Elliott,S. Scully,Hailing Hsu,John K. Sullivan,Nessa Hawkins,E. Davy,C. Capparelli,Alana Eli,Yi-xin Qian,Steve Kaufman,Ildiko Sarosi,Victoria Shalhoub,Giorgio Senaldi,Jane Guo,John M. Delaney,William J. Boyle +23 more
TL;DR: The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGl and OPG are key extracellular regulators of osteoclast development.
Journal ArticleDOI
Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
A. Michael Parfitt,Marc K. Drezner,Francis H. Glorieux,John A. Kanis,Hartmut H. Malluche,Pierre J. Meunier,Susan M. Ott,Robert R. Recker +7 more
TL;DR: A committee of the Society to develop a unified system of termnology, suitable for adoption by the Journal of Bone and Mineral Research as part of its Instructions to Authors is formed, and is as complex and conceptually difficult as the field with which it deals.
Journal ArticleDOI
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Kyoji Yamaguchi,Masahiko Kinosaki,Shin Ichi Mochizuki,Akihiro Tomoyasu,Kazuki Yano,Masaaki Goto,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Nobuyuki Udagawa,Naoyuki Takahashi,Tatsuo Suda +15 more
TL;DR: In this article, a membrane-bound osteoclast differentiation factor (ODF) was found to induce OCL formation from osteoblasts/stromal cells in the presence of bone-resorbing factors.
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