Journal ArticleDOI
Matrix metalloproteinases inhibitors in idiopathic pulmonary fibrosis: Medicinal chemistry perspectives.
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In this paper, the authors present the latest developments in MMP inhibitors, including pharmacophores, binding modes, selectivity and optimization strategies, and discuss the future development direction of MMP inhibitor based on emerging tools and techniques.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2021-07-20. It has received 9 citations till now. The article focuses on the topics: Idiopathic pulmonary fibrosis.read more
Citations
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Journal ArticleDOI
Epigenetic regulation in fibrosis progress.
Taixiong Xue,Xingyu Qiu,Hongyao Liu,Cailing Gan,Zui Tan,Yuting Xie,Yuxi Wang,Yuxi Wang,Tinghong Ye +8 more
TL;DR: In this article, the potential and prospect of targeted therapy for fibrosis based on epigenetic is discussed, focusing on heart, liver, lung and kidney, and the diversity of epigenetics in the cellular and molecular mechanisms related to fibrosis.
Journal ArticleDOI
Research Progress in the Molecular Mechanisms, Therapeutic Targets, and Drug Development of Idiopathic Pulmonary Fibrosis
Hong-Bo Ma,Xuyi Wu,Yi Li,Yu Xia +3 more
TL;DR: This study summarized the pathogenic mechanism, therapeutic targets and clinical trials of IPF from the perspective of multiple cell types, gene mutations, epigenetic and environmental factors.
Journal ArticleDOI
Physiological Properties, Functions, and Trends in the Matrix Metalloproteinase Inhibitors in Inflammation-Mediated Human Diseases.
TL;DR: The developments in the research examining the general and selective inhibitors for MMP associated with various human diseases over the past 20 years are described in terms of structure remodeling, substrate-recognizing specificities, and pharmacological applicability.
Journal ArticleDOI
Application and Study of ROCK Inhibitors in Pulmonary Fibrosis: Recent Developments and Future Perspectives.
TL;DR: In this article , the authors describe the structure-activity relationship, potency, selectivity, binding modes, pharmacokinetics (PKs), biological functions, and recently reported inhibitors of ROCKs in the context of Pulmonary fibrosis.
Journal ArticleDOI
Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.
TL;DR: In this article , a site-specific bioorthogonal mono-PEGylation was proposed to improve the half-life of TIMP2 without impairing its biological activity.
References
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Journal ArticleDOI
An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-Based Guidelines for Diagnosis and Management
Ganesh Raghu,Harold R. Collard,Jim J. Egan,Fernando J. Martinez,Juergen Behr,Kevin K. Brown,Thomas V. Colby,Jean-François Cordier,Kevin R. Flaherty,Joseph A. Lasky,David A. Lynch,Jay H. Ryu,Jeffrey J. Swigris,Athol U. Wells,Julio Ancochea,Demosthenes Bouros,Carlos Roberto Ribeiro de Carvalho,Ulrich Costabel,Masahito Ebina,David M. Hansell,Takeshi Johkoh,Dong Soon Kim,Talmadge E. King,Yasuhiro Kondoh,Jeffrey L. Myers,Nestor L. Müller,Andrew G. Nicholson,Luca Richeldi,Moisés Selman,Rosalind F. Dudden,Barbara S. Griss,Shandra Protzko,Holger J. Schünemann +32 more
TL;DR: This document represents the current state of knowledge regarding idiopathic pulmonary fibrosis, and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course.
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On the size of the active site in proteases. I. Papain.
Israel Schechter,Arieh Berger +1 more
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Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.
Robert Visse,Hideaki Nagase +1 more
TL;DR: This review describes the members of the matrixin family and discusses substrate specificity, domain structure and function, the activation of proMMPs, the regulation of matrixin activity by tissue inhibitors of metalloproteinases, and their pathophysiological implication.
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Structure and function of matrix metalloproteinases and TIMPs
TL;DR: The members of the MMP family are introduced and their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology are discussed.
Journal ArticleDOI
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Gabriele Bergers,Rolf A. Brekken,Gerald McMahon,Thiennu H. Vu,Takeshi Itoh,Kazuhiko Tamaki,Kazuhiko Tanzawa,Philip E. Thorpe,Shigeyoshi Itohara,Zena Werb,Douglas Hanahan +10 more
TL;DR: The results show that MMP-9 is a component of theAngiogenic switch, and MMP inhibitors reduce angiogenic switching, and tumour number and growth, as does genetic ablation of M MP-9.